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Literature summary extracted from

  • Sakurai, T.; Johnson, J.H.; Uyeda, K.
    Islet fructose 6-phosphate, 2-kinase: fructose 2,6-bisphosphatase: isozymic form, expression, and characterization (1996), Biochem. Biophys. Res. Commun., 218, 159-163.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.46 citrate
-
Rattus norvegicus
3.1.3.46 phosphoenolpyruvate
-
Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.105
-
Rattus norvegicus
2.7.1.105
-
Bos taurus
3.1.3.46 expression in Escherichia coli Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.105 citrate
-
Bos taurus
2.7.1.105 citrate
-
Rattus norvegicus
2.7.1.105 additional information
-
Bos taurus
2.7.1.105 additional information the islet enzyme lacks protein kinase A and C phosphorylation sites Rattus norvegicus
2.7.1.105 phosphoenolpyruvate
-
Bos taurus
2.7.1.105 phosphoenolpyruvate
-
Rattus norvegicus
3.1.3.46 6-phospho-gluconate
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.105 0.016
-
beta-D-fructose 6-phosphate pH 7.5, 25°C, liver Rattus norvegicus
2.7.1.105 0.017
-
beta-D-fructose 6-phosphate pH 7.5, 25°C, islet Rattus norvegicus
2.7.1.105 0.023
-
beta-D-fructose 6-phosphate pH 7.5, 25°C, heart Bos taurus
2.7.1.105 0.04
-
beta-D-fructose 6-phosphate pH 7.5, 25°C, testis Rattus norvegicus
2.7.1.105 0.048
-
ATP pH 7.5, 25°C, heart Rattus norvegicus
2.7.1.105 0.056
-
beta-D-fructose 6-phosphate pH 7.5, 25°C, muscle Rattus norvegicus
2.7.1.105 0.083
-
ATP pH 7.5, 25°C, heart Bos taurus
2.7.1.105 0.1
-
ATP
-
Bos taurus
2.7.1.105 0.1
-
ATP pH 7.5, 25°C, testis Rattus norvegicus
2.7.1.105 0.31
-
ATP pH 7.5, 25°C, liver Rattus norvegicus
2.7.1.105 0.328
-
ATP pH 7.5, 25°C, islet Rattus norvegicus
3.1.3.46 0.0003
-
fructose 2,6-bisphosphate
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate Rattus norvegicus responsible for regulation of fructose 2,6-bisphosphate-concentration ADP + beta-D-fructose 2,6-bisphosphate
-
?
2.7.1.105 ATP + beta-D-fructose 6-phosphate Bos taurus responsible for regulation of fructose 2,6-bisphosphate-concentration ADP + beta-D-fructose 2,6-bisphosphate
-
?
3.1.3.46 fructose 2,6-bisphosphate + H2O Rattus norvegicus
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.105 Bos taurus
-
-
-
2.7.1.105 Rattus norvegicus
-
-
-
3.1.3.46 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.105 phosphoprotein
-
Bos taurus
2.7.1.105 phosphoprotein the islet enzyme lacks protein kinase A and C phosphorylation sites Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.105 recombinant enzyme Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.105 ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Rattus norvegicus
2.7.1.105 ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Bos taurus
2.7.1.105 ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate high 6-phosphofructo-2-kinase activity compared to the fructose 2,6-bisphosphatase Rattus norvegicus
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.105 heart
-
Rattus norvegicus
-
2.7.1.105 heart
-
Bos taurus
-
2.7.1.105 liver
-
Rattus norvegicus
-
2.7.1.105 liver
-
Bos taurus
-
2.7.1.105 pancreatic islet
-
Rattus norvegicus
-
2.7.1.105 skeletal muscle
-
Rattus norvegicus
-
2.7.1.105 testis
-
Rattus norvegicus
-
3.1.3.46 pancreatic islet
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate
-
Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
r
2.7.1.105 ATP + beta-D-fructose 6-phosphate
-
Bos taurus ADP + beta-D-fructose 2,6-bisphosphate
-
r
2.7.1.105 ATP + beta-D-fructose 6-phosphate responsible for regulation of fructose 2,6-bisphosphate-concentration Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
?
2.7.1.105 ATP + beta-D-fructose 6-phosphate responsible for regulation of fructose 2,6-bisphosphate-concentration Bos taurus ADP + beta-D-fructose 2,6-bisphosphate
-
?
2.7.1.105 additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Rattus norvegicus ?
-
?
2.7.1.105 additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Bos taurus ?
-
?
3.1.3.46 fructose 2,6-bisphosphate + H2O
-
Rattus norvegicus fructose 6-phosphate + phosphate
-
?
3.1.3.46 fructose 2,6-bisphosphate + H2O
-
Rattus norvegicus ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.105 25
-
assay at Rattus norvegicus
2.7.1.105 25
-
assay at Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.105 0.08
-
phosphoenolpyruvate pH 7.5, 25°C, islet Rattus norvegicus