EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.3.46 | citrate | - |
Rattus norvegicus | |
3.1.3.46 | phosphoenolpyruvate | - |
Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.105 | - |
Rattus norvegicus |
2.7.1.105 | - |
Bos taurus |
3.1.3.46 | expression in Escherichia coli | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.105 | citrate | - |
Bos taurus | |
2.7.1.105 | citrate | - |
Rattus norvegicus | |
2.7.1.105 | additional information | - |
Bos taurus | |
2.7.1.105 | additional information | the islet enzyme lacks protein kinase A and C phosphorylation sites | Rattus norvegicus | |
2.7.1.105 | phosphoenolpyruvate | - |
Bos taurus | |
2.7.1.105 | phosphoenolpyruvate | - |
Rattus norvegicus | |
3.1.3.46 | 6-phospho-gluconate | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.105 | 0.016 | - |
beta-D-fructose 6-phosphate | pH 7.5, 25°C, liver | Rattus norvegicus | |
2.7.1.105 | 0.017 | - |
beta-D-fructose 6-phosphate | pH 7.5, 25°C, islet | Rattus norvegicus | |
2.7.1.105 | 0.023 | - |
beta-D-fructose 6-phosphate | pH 7.5, 25°C, heart | Bos taurus | |
2.7.1.105 | 0.04 | - |
beta-D-fructose 6-phosphate | pH 7.5, 25°C, testis | Rattus norvegicus | |
2.7.1.105 | 0.048 | - |
ATP | pH 7.5, 25°C, heart | Rattus norvegicus | |
2.7.1.105 | 0.056 | - |
beta-D-fructose 6-phosphate | pH 7.5, 25°C, muscle | Rattus norvegicus | |
2.7.1.105 | 0.083 | - |
ATP | pH 7.5, 25°C, heart | Bos taurus | |
2.7.1.105 | 0.1 | - |
ATP | - |
Bos taurus | |
2.7.1.105 | 0.1 | - |
ATP | pH 7.5, 25°C, testis | Rattus norvegicus | |
2.7.1.105 | 0.31 | - |
ATP | pH 7.5, 25°C, liver | Rattus norvegicus | |
2.7.1.105 | 0.328 | - |
ATP | pH 7.5, 25°C, islet | Rattus norvegicus | |
3.1.3.46 | 0.0003 | - |
fructose 2,6-bisphosphate | - |
Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | Rattus norvegicus | responsible for regulation of fructose 2,6-bisphosphate-concentration | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | Bos taurus | responsible for regulation of fructose 2,6-bisphosphate-concentration | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
3.1.3.46 | fructose 2,6-bisphosphate + H2O | Rattus norvegicus | - |
? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.105 | Bos taurus | - |
- |
- |
2.7.1.105 | Rattus norvegicus | - |
- |
- |
3.1.3.46 | Rattus norvegicus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.1.105 | phosphoprotein | - |
Bos taurus |
2.7.1.105 | phosphoprotein | the islet enzyme lacks protein kinase A and C phosphorylation sites | Rattus norvegicus |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.105 | recombinant enzyme | Rattus norvegicus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.7.1.105 | ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate | bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 | Rattus norvegicus | |
2.7.1.105 | ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate | bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 | Bos taurus | |
2.7.1.105 | ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate | high 6-phosphofructo-2-kinase activity compared to the fructose 2,6-bisphosphatase | Rattus norvegicus | |
3.1.3.46 | beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.105 | heart | - |
Rattus norvegicus | - |
2.7.1.105 | heart | - |
Bos taurus | - |
2.7.1.105 | liver | - |
Rattus norvegicus | - |
2.7.1.105 | liver | - |
Bos taurus | - |
2.7.1.105 | pancreatic islet | - |
Rattus norvegicus | - |
2.7.1.105 | skeletal muscle | - |
Rattus norvegicus | - |
2.7.1.105 | testis | - |
Rattus norvegicus | - |
3.1.3.46 | pancreatic islet | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | - |
Rattus norvegicus | ADP + beta-D-fructose 2,6-bisphosphate | - |
r | |
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | - |
Bos taurus | ADP + beta-D-fructose 2,6-bisphosphate | - |
r | |
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | responsible for regulation of fructose 2,6-bisphosphate-concentration | Rattus norvegicus | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | responsible for regulation of fructose 2,6-bisphosphate-concentration | Bos taurus | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
2.7.1.105 | additional information | also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) | Rattus norvegicus | ? | - |
? | |
2.7.1.105 | additional information | also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) | Bos taurus | ? | - |
? | |
3.1.3.46 | fructose 2,6-bisphosphate + H2O | - |
Rattus norvegicus | fructose 6-phosphate + phosphate | - |
? | |
3.1.3.46 | fructose 2,6-bisphosphate + H2O | - |
Rattus norvegicus | ? | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.105 | 25 | - |
assay at | Rattus norvegicus |
2.7.1.105 | 25 | - |
assay at | Bos taurus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.105 | 0.08 | - |
phosphoenolpyruvate | pH 7.5, 25°C, islet | Rattus norvegicus |