Literature summary extracted from

Pilkis, S.J.; Chrisman, T.; Burgress, B.; McGrane, M.; Colosia, A.; Pilkis, J.; Claus, T.H.; El-Maghrabi, M.R.
Rat hepatic 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase: a unique bifunctional enzyme (1983), Adv. Enzyme Regul., 21, 147-173.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.1.3.46	Cyclic AMP dependent protein kinase	-	Rattus norvegicus
3.1.3.46	epinephrine	-	Rattus norvegicus
3.1.3.46	glucagon	-	Rattus norvegicus
3.1.3.46	glycerol 1-phosphate	-	Rattus norvegicus
3.1.3.46	phosphate	-	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.3.46	fructose 6-phosphate	-	Rattus norvegicus
3.1.3.46	Insulin	opposes action of glucagon or epinephrine	Rattus norvegicus

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.1.3.46	100000	-	gel filtration	Rattus norvegicus
3.1.3.46	110000	-	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.3.46	fructose 2,6-bisphosphate + H2O	Rattus norvegicus	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.3.46	Rattus norvegicus	-	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
3.1.3.46	beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate	bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase	Rattus norvegicus	a

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.3.46	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.3.46	fructose 2,6-bisphosphate + H2O	-	Rattus norvegicus	fructose 6-phosphate + phosphate	-	?
3.1.3.46	fructose 2,6-bisphosphate + H2O	-	Rattus norvegicus	?	-	?

Subunits

EC Number	Subunits	Comment	Organism
3.1.3.46	dimer	2 * 50000-55000, SDS-PAGE	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)