EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.105 | iodoacetamide | activation, kidney and liver, not heart or testis enzyme | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.105 | additional information | phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme | Bos taurus | |
2.7.1.105 | additional information | phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme, not of kidney, testis and heart enzyme | Rattus norvegicus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.105 | Mg2+ | - |
Rattus norvegicus | |
2.7.1.105 | Mg2+ | - |
Bos taurus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.1.105 | 55000 | - |
2 * 55000, SDS-PAGE | Rattus norvegicus |
2.7.1.105 | 107000 | 109000 | equilibrium sedimentation, sedimentation velocity analysis | Rattus norvegicus |
3.1.3.46 | 107000 | - |
equilibrium sedimentation | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | Bos taurus | - |
ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | Rattus norvegicus | enzyme plays an important role in the regulation of hepatic carbohydrate metabolism | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
3.1.3.46 | fructose 2,6-bisphosphate + H2O | Rattus norvegicus | - |
? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.105 | Bos taurus | - |
- |
- |
2.7.1.105 | Canis lupus familiaris | - |
- |
- |
2.7.1.105 | Rattus norvegicus | - |
- |
- |
3.1.3.46 | Rattus norvegicus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.1.105 | phosphoprotein | phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme, not of kidney, testis and heart enzyme | Rattus norvegicus |
2.7.1.105 | phosphoprotein | phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme | Rattus norvegicus |
2.7.1.105 | phosphoprotein | phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme | Bos taurus |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.105 | - |
Rattus norvegicus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.1.3.46 | beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate | bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.105 | heart | - |
Rattus norvegicus | - |
2.7.1.105 | heart | - |
Bos taurus | - |
2.7.1.105 | kidney | - |
Rattus norvegicus | - |
2.7.1.105 | liver | - |
Rattus norvegicus | - |
2.7.1.105 | liver | - |
Bos taurus | - |
2.7.1.105 | liver | - |
Canis lupus familiaris | - |
2.7.1.105 | lung | - |
Rattus norvegicus | - |
2.7.1.105 | additional information | tissue distribution, in extrahepatic tissue only 10% or less of activity in liver | Rattus norvegicus | - |
2.7.1.105 | skeletal muscle | - |
Rattus norvegicus | - |
2.7.1.105 | testis | - |
Rattus norvegicus | - |
3.1.3.46 | adipose tissue | - |
Rattus norvegicus | - |
3.1.3.46 | brain | - |
Rattus norvegicus | - |
3.1.3.46 | kidney | - |
Rattus norvegicus | - |
3.1.3.46 | liver | - |
Rattus norvegicus | - |
3.1.3.46 | lung | - |
Rattus norvegicus | - |
3.1.3.46 | muscle | skeletal | Rattus norvegicus | - |
3.1.3.46 | spleen | - |
Rattus norvegicus | - |
3.1.3.46 | testis | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | - |
Rattus norvegicus | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | - |
Bos taurus | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | - |
Canis lupus familiaris | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | enzyme plays an important role in the regulation of hepatic carbohydrate metabolism | Rattus norvegicus | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
2.7.1.105 | additional information | also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) | Rattus norvegicus | ? | - |
? | |
2.7.1.105 | additional information | also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) | Bos taurus | ? | - |
? | |
2.7.1.105 | additional information | also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) | Canis lupus familiaris | ? | - |
? | |
2.7.1.105 | additional information | allosteric bifunctional enzyme, not heart | Rattus norvegicus | ? | - |
? | |
3.1.3.46 | fructose 2,6-bisphosphate + H2O | - |
Rattus norvegicus | fructose 6-phosphate + phosphate | - |
? | |
3.1.3.46 | fructose 2,6-bisphosphate + H2O | - |
Rattus norvegicus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.1.105 | dimer | - |
Bos taurus |
2.7.1.105 | dimer | - |
Canis lupus familiaris |
2.7.1.105 | dimer | 2 * 55000, SDS-PAGE | Rattus norvegicus |
3.1.3.46 | dimer | 2 * 50000-55000, SDS-PAGE | Rattus norvegicus |