Literature summary extracted from

Kaku, K.; Matsuda, M.; Matsutani, A.; Kaneko, T.
Effect of tolbutamide on fructose-6-phosphate,2-kinase and fructose-2,6-bisphosphatase in rat liver (1986), Biochem. Biophys. Res. Commun., 139, 687-692.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.1.3.46	glucagon	-	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.3.46	Tolbutamide	-	Rattus norvegicus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
3.1.3.46	0.002	-	fructose 2,6-bisphosphate	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.3.46	fructose 2,6-bisphosphate + H2O	Rattus norvegicus	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.3.46	Rattus norvegicus	-	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
3.1.3.46	beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate	bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase	Rattus norvegicus	a

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.3.46	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.3.46	fructose 2,6-bisphosphate + H2O	-	Rattus norvegicus	fructose 6-phosphate + phosphate	-	?
3.1.3.46	fructose 2,6-bisphosphate + H2O	-	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)