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Literature summary extracted from

  • Kretschmer, M.; Schellenberger, W.; Otto, A.; Kessler, R.; Hofmann, E.
    Fructose-2,6-bisphosphatase and 6-phosphofructo-2-kinase are separable in yeast (1987), Biochem. J., 246, 755-759.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.46 glycerol 1-phosphate counteracts fructose 6-phosphate inhibition Saccharomyces cerevisiae
3.1.3.46 Protein phosphatase 2A cyclic AMP dependent protein kinase inactivation reversible by Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.46 Cyclic AMP dependent protein kinase causes inactivation Saccharomyces cerevisiae
3.1.3.46 fructose 6-phosphate
-
Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.46 0.0001
-
fructose 2,6-bisphosphate
-
Saccharomyces cerevisiae
3.1.3.46 0.0003
-
fructose 2,6-bisphosphate
-
Saccharomyces cerevisiae

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.105 Mg2+
-
Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.46 fructose 2,6-bisphosphate + H2O Saccharomyces cerevisiae
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.105 Saccharomyces cerevisiae
-
-
-
3.1.3.46 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.105
-
Saccharomyces cerevisiae
3.1.3.46
-
Saccharomyces cerevisiae

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate bifunctional enzyme: 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.105 additional information
-
-
Saccharomyces cerevisiae

Storage Stability

EC Number Storage Stability Organism
3.1.3.46 -20°C, 20% glycerol Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate
-
Saccharomyces cerevisiae ADP + beta-D-fructose 2,6-bisphosphate
-
?
3.1.3.46 fructose 2,6-bisphosphate + H2O
-
Saccharomyces cerevisiae fructose 6-phosphate + phosphate
-
?
3.1.3.46 fructose 2,6-bisphosphate + H2O
-
Saccharomyces cerevisiae ?
-
?