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Literature summary extracted from
- Pyruvate dehydrogenase phosphatase from bovine heart (1982), Methods Enzymol., 90, 402-407.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.43 | F- | - |
Bos taurus |  |
| 3.1.3.43 | NADH | - |
Bos taurus | |
| 3.1.3.43 | phosphate | - |
Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.3.43 | 0.058 | - |
[Pyruvate dehydrogenase (lipoamide)]-phosphate | - |
Bos taurus |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.43 | Ca2+ | - |
Bos taurus | |
| 3.1.3.43 | Mg2+ | Km: 2 mM | Bos taurus | |
| 3.1.3.43 | Mn2+ | - |
Bos taurus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.43 | 50000 | - |
1 * 97000 + 1 * 50000, SDS-PAGE, heterodimer | Bos taurus |
| 3.1.3.43 | 97000 | - |
1 * 97000 + 1 * 50000, SDS-PAGE, heterodimer | Bos taurus |
| 3.1.3.43 | 150000 | - |
sedimentation equilibrium and gel filtration | Bos taurus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.43 | [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | Bos taurus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.43 | Bos taurus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.3.43 | assay method | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.3.43 | heart | - |
Bos taurus | - |
| 3.1.3.43 | kidney | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.43 | [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | - |
Bos taurus | [pyruvate dehydrogenase (lipoamide)] + phosphate | - |
ir | |
| 3.1.3.43 | [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | - |
Bos taurus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.3.43 | dimer | 1 * 97000 + 1 * 50000, SDS-PAGE, heterodimer | Bos taurus |
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Release 2023.1 (January 2023)
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