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Literature summary extracted from

  • Hoylaerts, M.F.; Manes, T.; Millan, J.L.
    Molecular mechanism of uncompetitive inhibition of human placental and germ-cell alkaline phosphatase (1992), Biochem. J., 286, 23-30.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.1 R166A mutation changes the inhibition mechanism of the mutant enzyme to a more complex mixed-type inhibition with decreased affinities for L-Leu and L-Phe Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.1 Leu L-Leu, uncompetitive, D-Leu with greatly decreased efficiencies Homo sapiens
3.1.3.1 leucinamide
-
 Homo sapiens
3.1.3.1 leucinol
-
 Homo sapiens
3.1.3.1 Phe L-Phe, uncompetitive, D-Phe with greatly decreased efficiencies Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.1 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.1 p-nitrophenyl phosphate + H2O
-
 Homo sapiens p-nitrophenol + phosphate
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.3.1 additional information
-
 additional information
-
 Homo sapiens