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Literature summary extracted from

  • Harkness, D.R.
    Studies on human placental alkaline phosphatase. II. Kinetic properties and studies on the apoenzyme (1968), Arch. Biochem. Biophys., 126, 513-523.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.1 arsenate
-
 Homo sapiens
3.1.3.1 EDTA optimal reactivation by Zn2+ or Co2+. The Zn2+-reactivated enzyme is stable, the Co2+-apoenzyme is not Homo sapiens
3.1.3.1 Mg2+
-
 Homo sapiens
3.1.3.1 NaCN
-
 Homo sapiens
3.1.3.1 Phenanthroline
-
 Homo sapiens
3.1.3.1 phosphate
-
 Homo sapiens
3.1.3.1 Trimetaphosphate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.1 0.8
-
 p-nitrophenyl phosphate
-
 Homo sapiens
3.1.3.1 1.4
-
 beta-Glycerophosphate
-
 Homo sapiens
3.1.3.1 2.3
-
 3'-AMP
-
 Homo sapiens
3.1.3.1 2.5
-
 2'-AMP
-
 Homo sapiens
3.1.3.1 2.9
-
 Phosphoethanolamine
-
 Homo sapiens
3.1.3.1 3
-
 5'-AMP
-
 Homo sapiens
3.1.3.1 4
-
 diphosphate
-
 Homo sapiens
3.1.3.1 4.4
-
 ADP
-
 Homo sapiens
3.1.3.1 4.5
-
 5'-dTMP
-
 Homo sapiens
3.1.3.1 4.8
-
 glucose 1-phosphate
-
 Homo sapiens
3.1.3.1 5.7
-
 ATP
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.1 Zn2+ Zn2+-metalloenzyme Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.1 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.1 2'-AMP + H2O
-
 Homo sapiens adenosine + phosphate
-
 ?
3.1.3.1 2-phosphoglycerate + H2O
-
 Homo sapiens glycerol + phosphate
-
 ?
3.1.3.1 3'-AMP + H2O
-
 Homo sapiens adenosine + phosphate
-
 ?
3.1.3.1 5'-AMP + H2O
-
 Homo sapiens adenosine + phosphate
-
 ?
3.1.3.1 5'-dTMP + H2O
-
 Homo sapiens ?
-
 ?
3.1.3.1 ADP + H2O
-
 Homo sapiens ?
-
 ?
3.1.3.1 ATP + H2O
-
 Homo sapiens ?
-
 ?
3.1.3.1 beta-glycerophosphate + H2O
-
 Homo sapiens glycerol + phosphate
-
 ?
3.1.3.1 diphosphate + H2O
-
 Homo sapiens 2 phosphate
-
 ?
3.1.3.1 glucose 1-phosphate + H2O
-
 Homo sapiens glucose + phosphate
-
 ?
3.1.3.1 p-nitrophenyl phosphate + H2O
-
 Homo sapiens p-nitrophenol + phosphate
-
 ?
3.1.3.1 phosphoethanolamine + H2O
-
 Homo sapiens phosphate + ethanolamine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.1 10.5
-
 hydrolysis of beta-glycerophosphate Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.3.1 9.5 11.5 pH 9.5: about 40% of maximal activity, pH 11.5: about 45% of maximal activity, hydrolysis of beta-glycerophosphate Homo sapiens