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Literature summary extracted from

  • Shimomura, Y.; Murakami, T.; Fujitsuka, N.; Nakai, N.; Sato, Y.; Sugiyama, S.; Shimomura, N.; Irwin, J.; Hawes, J.W.; Harris, R.A.
    Purification and partial characterization of 3-hydroxyisobutyryl-coenzyme A hydrolase of rat liver (1994), J. Biol. Chem., 269, 14248-14253.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.4 acetoacetyl-CoA competitive Rattus norvegicus
3.1.2.4 acetyl-CoA competitive Rattus norvegicus
3.1.2.4 DL-3-hydroxybutyryl-CoA competitive Rattus norvegicus
3.1.2.4 DL-methylmalonyl-CoA competitive Rattus norvegicus
3.1.2.4 isobutyryl-CoA competitive Rattus norvegicus
3.1.2.4 malonyl-CoA competitive Rattus norvegicus
3.1.2.4 n-valeryl-CoA competitive Rattus norvegicus
3.1.2.4 propionyl-CoA competitive Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.2.4 0.006
-
3-hydroxy-2-methylpropanoyl-CoA
-
Rattus norvegicus
3.1.2.4 0.025
-
3-hydroxypropionyl-CoA
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.4 mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.2.4 36000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.4 3-hydroxy-2-methylpropanoyl-CoA + H2O Rattus norvegicus enzyme is involved in Val catabolism. The enzyme protects cells against toxic effects of methacrylyl-CoA, an intermediate in the Val pathway occuring upstream of 3-hydroxy-2-methylpropanoyl-CoA ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.4 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.2.4
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.4 brain
-
Rattus norvegicus
-
3.1.2.4 heart
-
Rattus norvegicus
-
3.1.2.4 kidney
-
Rattus norvegicus
-
3.1.2.4 liver
-
Rattus norvegicus
-
3.1.2.4 muscle
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.2.4 427
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.4 (S)-methylmalonyl-CoA + H2O
-
Rattus norvegicus CoA + methylmalonate
-
?
3.1.2.4 3-hydroxy-2-methylpropanoyl-CoA + H2O
-
Rattus norvegicus CoA + 3-hydroxy-2-methylpropanoate
-
?
3.1.2.4 3-hydroxy-2-methylpropanoyl-CoA + H2O enzyme is involved in Val catabolism. The enzyme protects cells against toxic effects of methacrylyl-CoA, an intermediate in the Val pathway occuring upstream of 3-hydroxy-2-methylpropanoyl-CoA Rattus norvegicus ?
-
?
3.1.2.4 3-hydroxypropanoyl-CoA + H2O
-
Rattus norvegicus CoA + 3-hydroxypropanoate
-
?

Subunits

EC Number Subunits Comment Organism
3.1.2.4 monomer 1 * 36000, SDS-PAGE Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.2.4 150
-
3-hydroxy-2-methylpropanoyl-CoA
-
Rattus norvegicus
3.1.2.4 266
-
3-hydroxy-2-methylpropanoyl-CoA
-
Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.2.4 6
-
hydrolysis of (S)-methylmalonyl-CoA Rattus norvegicus
3.1.2.4 8
-
hydrolysis of 3-hydroxy-2-methylpropanoyl-CoA Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.2.4 5 7 pH 5.0, about 30% of maximal activity, pH 7.0: 65% of maximal activity, hydrolysis of (S)-methylmalonyl-CoA Rattus norvegicus
3.1.2.4 5 10.5 pH 5.0: about 40% of maximal activity, pH 10.5: about 80% of maximal activity, hydrolysis of 3-hydroxy-2-methylpropanoyl-CoA Rattus norvegicus