Literature summary extracted from

Ho, N.W.Y.
Methods for limiting the action of SP3 DNAase and for the determination of the direction of hydrolysis of processive exonucleases (1979), Biochim. Biophys. Acta, 563, 393-399.

Application

EC Number	Application	Comment	Organism
3.1.11.4	analysis	determination of the direction of hydrolysis of processive exonucleases	Enterobacteria phage SP

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.11.4	N-cyclohexyl-N'-beta-(4-methylmorpholinium)-ethylcarbodiimide-derivatized DNA	blocks enzyme activity absolutely, inhibition independent of nucleotide sequences	Enterobacteria phage SP

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.11.4	single-stranded DNA + H2O	Enterobacteria phage SP	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.11.4	Enterobacteria phage SP	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.11.4	infected cell	infected Bacillus subtilis	Enterobacteria phage SP	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.11.4	oligo- and polydeoxyribonucleotides + H2O	hydrolysis on polynucleotides from the 5-termini of single-stranded DNA	Enterobacteria phage SP	dinucleotide + oligonucleotide	-	?
3.1.11.4	single-stranded DNA + H2O	-	Enterobacteria phage SP	?	-	?
3.1.11.4	sorbitol-derivatized octanucleotides + H2O	-	Enterobacteria phage SP	dinucleotide + oligonucleotide	-	?

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Release 2023.1 (January 2023)