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Literature summary extracted from

  • Schauer, R.; Reuter, G.; Stoll, S.
    Sialate O-acetylesterases: key enzymes in sialic acid catabolism (1988), Biochimie, 70, 1511-1519.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.53 Cu2+
-
Equus caballus
3.1.1.53 Cu2+
-
influenza C virus
3.1.1.53 Diethyl-4-nitrophenylphosphate 50% inhibition at 0.0024 mM Bos taurus
3.1.1.53 Diethyl-4-nitrophenylphosphate
-
Equus caballus
3.1.1.53 Diethyl-4-nitrophenylphosphate 50% inhibition at 0.24 mM influenza C virus
3.1.1.53 diisopropyl fluorophosphate 50% inhibition at 0.35 mM Bos taurus
3.1.1.53 diisopropyl fluorophosphate
-
Equus caballus
3.1.1.53 diisopropyl fluorophosphate 50% inhibition at 0.01 mM influenza C virus
3.1.1.53 Hg2+ 50% inhibition at 0.0035 mM Bos taurus
3.1.1.53 Hg2+
-
Equus caballus
3.1.1.53 Hg2+
-
influenza C virus
3.1.1.53 N-acetyl-9-O-acetylneuraminate substrate inhibition above 2 mM influenza C virus
3.1.1.53 physostigmine 25% inhibition at 10 mM Bos taurus
3.1.1.53 physostigmine 25% inhibition at 10 mM influenza C virus
3.1.1.53 Zn2+
-
Equus caballus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.53 0.13
-
4-yethylumbelliferyl acetate
-
influenza C virus
3.1.1.53 0.17
-
4-yethylumbelliferyl acetate
-
Bos taurus
3.1.1.53 0.8
-
N-acetyl-9-O-acetylneuraminic acid
-
influenza C virus
3.1.1.53 0.9
-
N-acetyl-9-O-lactoylneuraminic acid
-
influenza C virus
3.1.1.53 1.1
-
N-acetyl-9-O-acetylneuraminic acid
-
Equus caballus
3.1.1.53 18
-
N-acetyl-9-O-acetylneuraminic acid
-
Bos taurus
3.1.1.53 24
-
N-acetyl-9-O-lactoylneuraminic acid
-
Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.53 30000
-
1 * 30000 + 1 * 65000, SDS-PAGE influenza C virus
3.1.1.53 56500
-
gel filtration Equus caballus
3.1.1.53 56500
-
gel filtration and SDS-PAGE Bos taurus
3.1.1.53 65000
-
1 * 30000 + 1 * 65000, SDS-PAGE influenza C virus
3.1.1.53 88000
-
gel fitration influenza C virus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.53 additional information Bos taurus O-acetylated sialic acids ?
-
?
3.1.1.53 additional information Equus caballus O-acetylated sialic acids ?
-
?
3.1.1.53 additional information influenza C virus O-acetylated sialic acids ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.53 Bos taurus
-
-
-
3.1.1.53 Equus caballus
-
-
-
3.1.1.53 influenza C virus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.53 180fold enrichment influenza C virus
3.1.1.53 2600fold enrichment Bos taurus
3.1.1.53 850fold enrichment Equus caballus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.53 brain
-
Bos taurus
-
3.1.1.53 liver
-
Equus caballus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.53 2-deoxy-2,3-didehydro-N-acetyl-9-O-acetylneuraminate + H2O 55% of the activity compared to N-acetyl-9-O-acetylneuraminate Bos taurus ?
-
?
3.1.1.53 2-deoxy-2,3-didehydro-N-acetyl-9-O-acetylneuraminate + H2O 37% of the activity compared to N-acetyl-9-O-acetylneuraminate influenza C virus ?
-
?
3.1.1.53 4-methylumbelliferyl acetate + H2O 130% of the activity compared to N-acetyl-9-O-acetylneuraminate Bos taurus 4-methylumbelliferone + acetate
-
?
3.1.1.53 4-methylumbelliferyl acetate + H2O 220% of the activity compared to N-acetyl-9-O-acetylneuraminate influenza C virus 4-methylumbelliferone + acetate
-
?
3.1.1.53 4-methylumbelliferyl butyrate + H2O 14% of the activity compared to N-acetyl-9-O-acetylneuraminate influenza C virus 4-methylumbelliferone + butyrate
-
?
3.1.1.53 4-nitrophenyl acetate + H2O 3500% of the activity compared to N-acetyl-9-O-acetylneuraminate influenza C virus 4-nitrophenol + acetate
-
?
3.1.1.53 4-nitrophenyl acetate + H2O 680% of the activity compared to N-acetyl-9-O-acetylneuraminate Bos taurus 4-nitrophenol + acetate
-
?
3.1.1.53 acetyl-CoA + H2O 2% of the activity compared to N-acetyl-9-O-acetylneuraminate Bos taurus CoA + acetate
-
?
3.1.1.53 alpha-naphthyl acetate + H2O 2200% of the activity compared to N-acetyl-9-O-acetylneuraminate influenza C virus 1-naphthol + acetate
-
?
3.1.1.53 alpha-naphthyl acetate + H2O 643% of the activity compared to N-acetyl-9-O-acetylneuraminate Bos taurus 1-naphthol + acetate
-
?
3.1.1.53 bovine submandibular gland mucin + H2O 30% of the activity compared to N-acetyl-9-O-acetylneuraminate influenza C virus ?
-
?
3.1.1.53 additional information no hydrolysis with N-acetyl-4-O-lactoylneuraminate, N-acetyl-9-O-acetylneuraminate methyl ester Bos taurus ?
-
?
3.1.1.53 additional information no hydrolysis with N-acetyl-4-O-lactoylneuraminate, N-acetyl-9-O-acetylneuraminate methyl ester influenza C virus ?
-
?
3.1.1.53 additional information no hydrolysis with acetyl-coenzyme A, acetylthiocholine iodide influenza C virus ?
-
?
3.1.1.53 additional information no hydrolysis with N-glycoloyl-9-O-lactoylneuraminate, bovine submandibular gland mucin, rat serum glycoprotein, rat erythrocytes Bos taurus ?
-
?
3.1.1.53 additional information no hydrolysis with N-acetyl-7-O-acetylneuraminate, horse alpha1-acid glycoprotein, N-acetylneuraminate methyl ester Bos taurus ?
-
?
3.1.1.53 additional information no hydrolysis with N-acetyl-7-O-acetylneuraminate, horse alpha1-acid glycoprotein, N-acetylneuraminate methyl ester Equus caballus ?
-
?
3.1.1.53 additional information no hydrolysis with N-acetyl-7-O-acetylneuraminate, horse alpha1-acid glycoprotein, N-acetylneuraminate methyl ester influenza C virus ?
-
?
3.1.1.53 additional information O-acetylated sialic acids Bos taurus ?
-
?
3.1.1.53 additional information O-acetylated sialic acids Equus caballus ?
-
?
3.1.1.53 additional information O-acetylated sialic acids influenza C virus ?
-
?
3.1.1.53 N-acetyl-4-O-acetylneuraminate + H2O 60% of the activity compared to N-acetyl-9-O-acetylneuraminate Bos taurus N-acetylneuraminate + acetate
-
?
3.1.1.53 N-acetyl-4-O-acetylneuraminate + H2O 3% of the activity compared to N-acetyl-9-O-acetylneuraminate influenza C virus N-acetylneuraminate + acetate
-
?
3.1.1.53 N-acetyl-4-O-acetylneuraminate + H2O no hydrolysis at pI 4.8, same rate of hydrolysis at pI 5.7 compared to N-acetyl-9-O-acetylneuraminate Equus caballus N-acetylneuraminate + acetate
-
?
3.1.1.53 N-acetyl-9-O-acetylneuraminate + H2O
-
Bos taurus N-acetylneuraminate + acetate
-
?
3.1.1.53 N-acetyl-9-O-acetylneuraminate + H2O
-
influenza C virus N-acetylneuraminate + acetate
-
?
3.1.1.53 N-acetyl-9-O-acetylneuraminate + H2O at pI 4.8 and pI 5.7 Equus caballus N-acetylneuraminate + acetate
-
?
3.1.1.53 N-acetyl-9-O-acetylneuraminate beta-methylglycoside + H2O 70% of the activity compared to N-acetyl-9-O-acetylneuraminate influenza C virus N-acetylneuraminate beta-methylglycoside + acetate
-
?
3.1.1.53 N-acetyl-9-O-acetylneuraminate lactose + H2O 96% of the activity compared to N-acetyl-9-O-acetylneuraminate influenza C virus N-acetylneuraminate lactose + acetate
-
?
3.1.1.53 N-acetyl-9-O-acetylneuraminate lactose + H2O same rate of hydrolysis compared to N-acetyl-9-O-acetylneuraminate Bos taurus N-acetylneuraminate lactose + acetate
-
?
3.1.1.53 N-acetyl-9-O-lactoylneuraminic acid + H2O
-
Bos taurus 9-O-lactoylneuraminic acid + acetate
-
?
3.1.1.53 N-acetyl-9-O-lactoylneuraminic acid + H2O
-
influenza C virus 9-O-lactoylneuraminic acid + acetate
-
?
3.1.1.53 rat serum glycoprotein + H2O 90% of the activity compared to N-acetyl-9-O-acetylneuraminate influenza C virus ?
-
?
3.1.1.53 thiophenyl acetate + H2O 12% of the activity compared to N-acetyl-9-O-acetylneuraminate influenza C virus thiophenol + acetate
-
?
3.1.1.53 thiophenyl acetate + H2O 305% of the activity compared to N-acetyl-9-O-acetylneuraminate Bos taurus thiophenol + acetate
-
?

Subunits

EC Number Subunits Comment Organism
3.1.1.53 dimer 1 * 30000 + 1 * 65000, SDS-PAGE influenza C virus
3.1.1.53 monomer 1* 56500, gel filtration and SDS-PAGE Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.53 7.4
-
-
Bos taurus
3.1.1.53 7.8
-
-
influenza C virus
3.1.1.53 8.5
-
-
Equus caballus