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Literature summary extracted from
- Purification of lysosomal phospholipase A and demonstration of proteins that inhibit phospholipase A in a lysosomal fraction from rat kidney cortex (1986), Biochemistry, 25, 6456-6461.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.32 | additional information | naturally occuring inhibitors of lysosomal phospholipase A are present in two of the lysosomal-soluble protein fractions obtained in the purification | Rattus norvegicus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.1.32 | lysosome | - |
Rattus norvegicus | 5764 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.32 | Hg2+ | not required | Rattus norvegicus |  |
| 3.1.1.32 | Hg2+ | 2.0 mM, stimulates | Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.32 | 30000 | - |
gel filtration | Rattus norvegicus |
| 3.1.1.32 | 34000 | - |
x * 34000, SDS-PAGE | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.32 | Rattus norvegicus | - |
one isoenzyme in kidney | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.1.1.32 | side-chain modification | glycoprotein | Rattus norvegicus |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.1.32 | - |
Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.1.32 | kidney | cortex, only one isoenzyme | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.32 | 1,2-dioleoylphosphatidylcholine + H2O | - |
Rattus norvegicus | oleic acid + 2-oleoylglycerophosphocholine | - |
? | |
| 3.1.1.32 | 1-palmitoyllysophosphatidylcholine + H2O | weak activity | Rattus norvegicus | palmitic acid + lysophosphatidylcholine | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.1.32 | ? | x * 34000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.32 | 3.6 | 3.8 | - |
Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.1.32 | 2.6 | 5.2 | pH 2.6: 83% of maximal activity, pH 4.5: 50% of maximal activity, pH 5.2: 10% of maximal activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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