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Literature summary extracted from

  • Heide, L.; Arendt, S.; Leistner, E.
    Enzymatic synthesis, characterization, and metabolism of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis (1982), J. Biol. Chem., 257, 7396-7400.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.36 additional information little or no inhibition by dimethylamide Escherichia coli
4.1.3.36 additional information little or no inhibition by dimethylamide Mycolicibacterium phlei

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.3.36 additional information no metal ion required Escherichia coli
4.1.3.36 additional information no metal ion required Mycolicibacterium phlei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.26 ATP + 2-succinylbenzoate + CoA Mycolicibacterium phlei o-succinylbenzoyl-CoA is an intermediate in menaquinone (vitamin K2) biosynthesis AMP + diphosphate + 2-succinylbenzoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.36 Escherichia coli
-
 K-12
-
4.1.3.36 Mycolicibacterium phlei
-
-
-
6.2.1.26 Mycolicibacterium phlei
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.36
-
 Escherichia coli
4.1.3.36
-
 Mycolicibacterium phlei

Storage Stability

EC Number Storage Stability Organism
4.1.3.36 -20°C, E. coli K-12, not less than 6 weeks Escherichia coli
4.1.3.36 -20°C, Mycobacterium phlei, in 3-(N-morpholino)propanesulfonic acid buffer, pH 6.9, 0.2 mM DTT, 20% DMSO, not less than 6 weeks Mycolicibacterium phlei

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.36 o-succinylbenzoyl-CoA
-
 Escherichia coli 1,4-dihydroxy-2-naphthoyl-CoA + H2O
-
 ?
4.1.3.36 o-succinylbenzoyl-CoA
-
 Mycolicibacterium phlei 1,4-dihydroxy-2-naphthoyl-CoA + H2O
-
 ?
6.2.1.26 ATP + 2-succinylbenzoate + CoA
-
 Mycolicibacterium phlei AMP + diphosphate + 2-succinylbenzoyl-CoA the o-succinylbenzoyl conenzyme A ester is unstable at alkaline and neutral pH, but is fairly stable under acid conditions ?
6.2.1.26 ATP + 2-succinylbenzoate + CoA o-succinylbenzoyl-CoA is an intermediate in menaquinone (vitamin K2) biosynthesis Mycolicibacterium phlei AMP + diphosphate + 2-succinylbenzoyl-CoA
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.3.36 additional information no cofactor required Escherichia coli
4.1.3.36 additional information no cofactor required Mycolicibacterium phlei