EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.24.11 | - |
Homo sapiens |
3.4.24.11 | - |
Rattus norvegicus |
3.4.24.11 | - |
Oryctolagus cuniculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.24.11 | E584D | no activity | Rattus norvegicus |
3.4.24.11 | E584V | no activity | Rattus norvegicus |
3.4.24.11 | H583F | enzymatic activity and Zn-directed inhibitor binding is abolished | Rattus norvegicus |
3.4.24.11 | H587F | enzymatic activity and Zn-directed inhibitor binding is abolished | Rattus norvegicus |
3.4.24.11 | H637F | no effect on activity | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.11 | Acetorphan | - |
Homo sapiens | |
3.4.24.11 | N-[(2RS)-3-hydroxyaminocarbonyl-2-benzyl-1-oxopropyl]-Gly | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.11 | membrane | - |
Homo sapiens | 16020 | - |
3.4.24.11 | membrane | - |
Rattus norvegicus | 16020 | - |
3.4.24.11 | membrane | axonal membranes, including those in synaptic junctions | Sus scrofa | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.11 | Zinc | - |
Sus scrofa | |
3.4.24.11 | Zinc | cofactor | Homo sapiens | |
3.4.24.11 | Zinc | cofactor | Rattus norvegicus | |
3.4.24.11 | Zinc | cofactor | Oryctolagus cuniculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.11 | additional information | Homo sapiens | the enzyme is the major inactivator of enkephalin in brain | ? | - |
? | |
3.4.24.11 | additional information | Rattus norvegicus | the enzyme is the major inactivator of enkephalin in brain | ? | - |
? | |
3.4.24.11 | additional information | Oryctolagus cuniculus | the enzyme is the major inactivator of enkephalin in brain | ? | - |
? | |
3.4.24.11 | additional information | Homo sapiens | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | ? | - |
? | |
3.4.24.11 | additional information | Rattus norvegicus | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | ? | - |
? | |
3.4.24.11 | additional information | Sus scrofa | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | ? | - |
? | |
3.4.24.11 | additional information | Oryctolagus cuniculus | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.11 | Homo sapiens | - |
- |
- |
3.4.24.11 | Oryctolagus cuniculus | - |
- |
- |
3.4.24.11 | Rattus norvegicus | - |
- |
- |
3.4.24.11 | Sus scrofa | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.24.11 | side-chain modification | - |
Sus scrofa |
3.4.24.11 | side-chain modification | five potential N-linked glycosylation sites | Oryctolagus cuniculus |
3.4.24.11 | side-chain modification | six potential N-linked glycosylation sites | Homo sapiens |
3.4.24.11 | side-chain modification | six potential N-linked glycosylation sites | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.11 | brain | - |
Homo sapiens | - |
3.4.24.11 | brain | in globus pallidus and substantia nigra much of the enzyme is associated with presynaptic nerve terminals originating from efferent striatal neurons | Rattus norvegicus | - |
3.4.24.11 | brain | corpus striatum and globus pallidus | Sus scrofa | - |
3.4.24.11 | central nervous system | - |
Homo sapiens | - |
3.4.24.11 | central nervous system | - |
Rattus norvegicus | - |
3.4.24.11 | central nervous system | - |
Sus scrofa | - |
3.4.24.11 | central nervous system | - |
Oryctolagus cuniculus | - |
3.4.24.11 | epithelium | - |
Homo sapiens | - |
3.4.24.11 | epithelium | - |
Rattus norvegicus | - |
3.4.24.11 | epithelium | - |
Oryctolagus cuniculus | - |
3.4.24.11 | fibroblast | - |
Homo sapiens | - |
3.4.24.11 | fibroblast | - |
Rattus norvegicus | - |
3.4.24.11 | fibroblast | - |
Oryctolagus cuniculus | - |
3.4.24.11 | intestine | - |
Homo sapiens | - |
3.4.24.11 | intestine | - |
Rattus norvegicus | - |
3.4.24.11 | intestine | - |
Oryctolagus cuniculus | - |
3.4.24.11 | kidney | - |
Homo sapiens | - |
3.4.24.11 | kidney | - |
Rattus norvegicus | - |
3.4.24.11 | kidney | renal brush border | Sus scrofa | - |
3.4.24.11 | kidney | renal brush border | Oryctolagus cuniculus | - |
3.4.24.11 | neutrophil | - |
Homo sapiens | - |
3.4.24.11 | neutrophil | - |
Rattus norvegicus | - |
3.4.24.11 | neutrophil | - |
Oryctolagus cuniculus | - |
3.4.24.11 | Schwann cell | present in many, but not all Schwann cell membranes | Sus scrofa | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.11 | alpha-neoendorphin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | alpha-neoendorphin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | alpha-neoendorphin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | angiotensin I + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | angiotensin I + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | angiotensin I + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | angiotensin II + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | angiotensin II + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | angiotensin II + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | - |
Sus scrofa | ? | - |
? | |
3.4.24.11 | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O | - |
Sus scrofa | ? | - |
? | |
3.4.24.11 | Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | Atrial natriuretic factor + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | Atrial natriuretic factor + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | Atrial natriuretic factor + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | beta-lipotropin(61-69) + H2O + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | beta-lipotropin(61-69) + H2O + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | beta-lipotropin(61-69) + H2O + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | beta-neoendorphin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | beta-neoendorphin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | beta-neoendorphin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | bradykinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | bradykinin + H2O | - |
Sus scrofa | ? | - |
? | |
3.4.24.11 | bradykinin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | dynorphin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | dynorphin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | dynorphin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | enkephalin + H2O | hydrolysis at Gly3-Phe4 | Homo sapiens | ? | - |
? | |
3.4.24.11 | enkephalin + H2O | hydrolysis at Gly3-Phe4 | Rattus norvegicus | ? | - |
? | |
3.4.24.11 | enkephalin + H2O | hydrolysis at Gly3-Phe4 | Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | FMRF amide + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | FMRF amide + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | FMRF amide + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | gamma-endorphin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | gamma-endorphin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | gamma-endorphin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | gastrin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | gastrin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | gastrin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | gastrin G-17 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | gastrin releasing peptide-10 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | gastrin releasing peptide-10 + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | gastrin releasing peptide-10 + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O | - |
Homo sapiens | His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2 | - |
? | |
3.4.24.11 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O | - |
Rattus norvegicus | His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2 | - |
? | |
3.4.24.11 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O | - |
Sus scrofa | His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2 | - |
? | |
3.4.24.11 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O | - |
Oryctolagus cuniculus | His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2 | - |
? | |
3.4.24.11 | insulin B chain + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | insulin B chain + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | insulin B chain + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | interleukin 1beta + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | interleukin 1beta + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | interleukin 1beta + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | Luteinizing hormone-releasing hormone + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | Luteinizing hormone-releasing hormone + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | Luteinizing hormone-releasing hormone + H2O | - |
Sus scrofa | ? | - |
? | |
3.4.24.11 | Luteinizing hormone-releasing hormone + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | Met-enkephalin-Arg6-Gly7-Leu + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | Met-enkephalin-Arg6-Gly7-Leu + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | Met-enkephalin-Arg6-Gly7-Leu + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | Met-Leu-Phe + H2O | chemotactic peptide | Homo sapiens | ? | - |
? | |
3.4.24.11 | Met-Leu-Phe + H2O | chemotactic peptide | Rattus norvegicus | ? | - |
? | |
3.4.24.11 | Met-Leu-Phe + H2O | chemotactic peptide | Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | Met5-enkephalin-Arg6-Phe7 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | Met5-enkephalin-Arg6-Phe7 + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | Met5-enkephalin-Arg6-Phe7 + H2O | - |
Sus scrofa | ? | - |
? | |
3.4.24.11 | Met5-enkephalin-Arg6-Phe7 + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | additional information | the enzyme is the major inactivator of enkephalin in brain | Homo sapiens | ? | - |
? | |
3.4.24.11 | additional information | the enzyme is the major inactivator of enkephalin in brain | Rattus norvegicus | ? | - |
? | |
3.4.24.11 | additional information | the enzyme is the major inactivator of enkephalin in brain | Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | additional information | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | Homo sapiens | ? | - |
? | |
3.4.24.11 | additional information | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | Rattus norvegicus | ? | - |
? | |
3.4.24.11 | additional information | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | Sus scrofa | ? | - |
? | |
3.4.24.11 | additional information | the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins | Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | neurokinin B + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | neurokinin B + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | neurokinin B + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | neurotensin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | neurotensin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | neurotensin + H2O | - |
Sus scrofa | ? | - |
? | |
3.4.24.11 | neurotensin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | oxytocin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | oxytocin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | oxytocin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
3.4.24.11 | physalaemin + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.24.11 | physalaemin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.11 | physalaemin + H2O | - |
Sus scrofa | ? | - |
? | |
3.4.24.11 | physalaemin + H2O | - |
Oryctolagus cuniculus | ? | - |
? |