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Literature summary extracted from

  • Erdös, E.G.; Skidgel, R.A.
    Neutral endopeptidase 24.11 (enkephalinase) and related regulators of peptide hormones (1989), FASEB J., 3, 145-151.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.11
-
Homo sapiens
3.4.24.11
-
Rattus norvegicus
3.4.24.11
-
Oryctolagus cuniculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.11 E584D no activity Rattus norvegicus
3.4.24.11 E584V no activity Rattus norvegicus
3.4.24.11 H583F enzymatic activity and Zn-directed inhibitor binding is abolished Rattus norvegicus
3.4.24.11 H587F enzymatic activity and Zn-directed inhibitor binding is abolished Rattus norvegicus
3.4.24.11 H637F no effect on activity Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.11 Acetorphan
-
Homo sapiens
3.4.24.11 N-[(2RS)-3-hydroxyaminocarbonyl-2-benzyl-1-oxopropyl]-Gly
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.11 membrane
-
Homo sapiens 16020
-
3.4.24.11 membrane
-
Rattus norvegicus 16020
-
3.4.24.11 membrane axonal membranes, including those in synaptic junctions Sus scrofa 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.11 Zinc
-
Sus scrofa
3.4.24.11 Zinc cofactor Homo sapiens
3.4.24.11 Zinc cofactor Rattus norvegicus
3.4.24.11 Zinc cofactor Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.11 additional information Homo sapiens the enzyme is the major inactivator of enkephalin in brain ?
-
?
3.4.24.11 additional information Rattus norvegicus the enzyme is the major inactivator of enkephalin in brain ?
-
?
3.4.24.11 additional information Oryctolagus cuniculus the enzyme is the major inactivator of enkephalin in brain ?
-
?
3.4.24.11 additional information Homo sapiens the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins ?
-
?
3.4.24.11 additional information Rattus norvegicus the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins ?
-
?
3.4.24.11 additional information Sus scrofa the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins ?
-
?
3.4.24.11 additional information Oryctolagus cuniculus the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.11 Homo sapiens
-
-
-
3.4.24.11 Oryctolagus cuniculus
-
-
-
3.4.24.11 Rattus norvegicus
-
-
-
3.4.24.11 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.11 side-chain modification
-
Sus scrofa
3.4.24.11 side-chain modification five potential N-linked glycosylation sites Oryctolagus cuniculus
3.4.24.11 side-chain modification six potential N-linked glycosylation sites Homo sapiens
3.4.24.11 side-chain modification six potential N-linked glycosylation sites Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.11 brain
-
Homo sapiens
-
3.4.24.11 brain in globus pallidus and substantia nigra much of the enzyme is associated with presynaptic nerve terminals originating from efferent striatal neurons Rattus norvegicus
-
3.4.24.11 brain corpus striatum and globus pallidus Sus scrofa
-
3.4.24.11 central nervous system
-
Homo sapiens
-
3.4.24.11 central nervous system
-
Rattus norvegicus
-
3.4.24.11 central nervous system
-
Sus scrofa
-
3.4.24.11 central nervous system
-
Oryctolagus cuniculus
-
3.4.24.11 epithelium
-
Homo sapiens
-
3.4.24.11 epithelium
-
Rattus norvegicus
-
3.4.24.11 epithelium
-
Oryctolagus cuniculus
-
3.4.24.11 fibroblast
-
Homo sapiens
-
3.4.24.11 fibroblast
-
Rattus norvegicus
-
3.4.24.11 fibroblast
-
Oryctolagus cuniculus
-
3.4.24.11 intestine
-
Homo sapiens
-
3.4.24.11 intestine
-
Rattus norvegicus
-
3.4.24.11 intestine
-
Oryctolagus cuniculus
-
3.4.24.11 kidney
-
Homo sapiens
-
3.4.24.11 kidney
-
Rattus norvegicus
-
3.4.24.11 kidney renal brush border Sus scrofa
-
3.4.24.11 kidney renal brush border Oryctolagus cuniculus
-
3.4.24.11 neutrophil
-
Homo sapiens
-
3.4.24.11 neutrophil
-
Rattus norvegicus
-
3.4.24.11 neutrophil
-
Oryctolagus cuniculus
-
3.4.24.11 Schwann cell present in many, but not all Schwann cell membranes Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.11 alpha-neoendorphin + H2O
-
Homo sapiens ?
-
?
3.4.24.11 alpha-neoendorphin + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 alpha-neoendorphin + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 angiotensin I + H2O
-
Homo sapiens ?
-
?
3.4.24.11 angiotensin I + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 angiotensin I + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 angiotensin II + H2O
-
Homo sapiens ?
-
?
3.4.24.11 angiotensin II + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 angiotensin II + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
-
Homo sapiens ?
-
?
3.4.24.11 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
-
Sus scrofa ?
-
?
3.4.24.11 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O
-
Homo sapiens ?
-
?
3.4.24.11 Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O
-
Sus scrofa ?
-
?
3.4.24.11 Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-PheNH2 + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 Atrial natriuretic factor + H2O
-
Homo sapiens ?
-
?
3.4.24.11 Atrial natriuretic factor + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 Atrial natriuretic factor + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 beta-lipotropin(61-69) + H2O + H2O
-
Homo sapiens ?
-
?
3.4.24.11 beta-lipotropin(61-69) + H2O + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 beta-lipotropin(61-69) + H2O + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 beta-neoendorphin + H2O
-
Homo sapiens ?
-
?
3.4.24.11 beta-neoendorphin + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 beta-neoendorphin + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 bradykinin + H2O
-
Homo sapiens ?
-
?
3.4.24.11 bradykinin + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 bradykinin + H2O
-
Sus scrofa ?
-
?
3.4.24.11 bradykinin + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 dynorphin + H2O
-
Homo sapiens ?
-
?
3.4.24.11 dynorphin + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 dynorphin + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 enkephalin + H2O hydrolysis at Gly3-Phe4 Homo sapiens ?
-
?
3.4.24.11 enkephalin + H2O hydrolysis at Gly3-Phe4 Rattus norvegicus ?
-
?
3.4.24.11 enkephalin + H2O hydrolysis at Gly3-Phe4 Oryctolagus cuniculus ?
-
?
3.4.24.11 FMRF amide + H2O
-
Homo sapiens ?
-
?
3.4.24.11 FMRF amide + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 FMRF amide + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 gamma-endorphin + H2O
-
Homo sapiens ?
-
?
3.4.24.11 gamma-endorphin + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 gamma-endorphin + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 gastrin + H2O
-
Homo sapiens ?
-
?
3.4.24.11 gastrin + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 gastrin + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 gastrin G-17 + H2O
-
Homo sapiens ?
-
?
3.4.24.11 gastrin releasing peptide-10 + H2O
-
Homo sapiens ?
-
?
3.4.24.11 gastrin releasing peptide-10 + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 gastrin releasing peptide-10 + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O
-
Homo sapiens His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2
-
?
3.4.24.11 His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O
-
Rattus norvegicus His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2
-
?
3.4.24.11 His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O
-
Sus scrofa His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2
-
?
3.4.24.11 His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2 + H2O
-
Oryctolagus cuniculus His-Lys-Thr-Asp-Ser + Phe-Val-Gly + Leu-Met-NH2
-
?
3.4.24.11 insulin B chain + H2O
-
Homo sapiens ?
-
?
3.4.24.11 insulin B chain + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 insulin B chain + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 interleukin 1beta + H2O
-
Homo sapiens ?
-
?
3.4.24.11 interleukin 1beta + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 interleukin 1beta + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 Luteinizing hormone-releasing hormone + H2O
-
Homo sapiens ?
-
?
3.4.24.11 Luteinizing hormone-releasing hormone + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 Luteinizing hormone-releasing hormone + H2O
-
Sus scrofa ?
-
?
3.4.24.11 Luteinizing hormone-releasing hormone + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 Met-enkephalin-Arg6-Gly7-Leu + H2O
-
Homo sapiens ?
-
?
3.4.24.11 Met-enkephalin-Arg6-Gly7-Leu + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 Met-enkephalin-Arg6-Gly7-Leu + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 Met-Leu-Phe + H2O chemotactic peptide Homo sapiens ?
-
?
3.4.24.11 Met-Leu-Phe + H2O chemotactic peptide Rattus norvegicus ?
-
?
3.4.24.11 Met-Leu-Phe + H2O chemotactic peptide Oryctolagus cuniculus ?
-
?
3.4.24.11 Met5-enkephalin-Arg6-Phe7 + H2O
-
Homo sapiens ?
-
?
3.4.24.11 Met5-enkephalin-Arg6-Phe7 + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 Met5-enkephalin-Arg6-Phe7 + H2O
-
Sus scrofa ?
-
?
3.4.24.11 Met5-enkephalin-Arg6-Phe7 + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 additional information the enzyme is the major inactivator of enkephalin in brain Homo sapiens ?
-
?
3.4.24.11 additional information the enzyme is the major inactivator of enkephalin in brain Rattus norvegicus ?
-
?
3.4.24.11 additional information the enzyme is the major inactivator of enkephalin in brain Oryctolagus cuniculus ?
-
?
3.4.24.11 additional information the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins Homo sapiens ?
-
?
3.4.24.11 additional information the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins Rattus norvegicus ?
-
?
3.4.24.11 additional information the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins Sus scrofa ?
-
?
3.4.24.11 additional information the enzyme may participate in the regulation of blood pressure and water and sodium excretion through inactivation of kinins Oryctolagus cuniculus ?
-
?
3.4.24.11 neurokinin B + H2O
-
Homo sapiens ?
-
?
3.4.24.11 neurokinin B + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 neurokinin B + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 neurotensin + H2O
-
Homo sapiens ?
-
?
3.4.24.11 neurotensin + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 neurotensin + H2O
-
Sus scrofa ?
-
?
3.4.24.11 neurotensin + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 oxytocin + H2O
-
Homo sapiens ?
-
?
3.4.24.11 oxytocin + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 oxytocin + H2O
-
Oryctolagus cuniculus ?
-
?
3.4.24.11 physalaemin + H2O
-
Homo sapiens ?
-
?
3.4.24.11 physalaemin + H2O
-
Rattus norvegicus ?
-
?
3.4.24.11 physalaemin + H2O
-
Sus scrofa ?
-
?
3.4.24.11 physalaemin + H2O
-
Oryctolagus cuniculus ?
-
?