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Literature summary extracted from
- Active site of bovine factor Xa. Characterization using substituted benzamidines as competitive inhibitors and affinity-labeling reagents (1980), J. Biol. Chem., 255, 2014-2021.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.6 | diisopropylfluorophosphate | - |
Bos taurus |  |
| 3.4.21.6 | m-(o-(2-chloro-5-fluorosulfonylphenylureido)phenoxybutoxy)benzamidine | - |
Bos taurus | |
| 3.4.21.6 | p-amidinophenylmethanesulfonyl fluoride | - |
Bos taurus | |
| 3.4.21.6 | p-nitrophenylguanidinobenzoate | - |
Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.6 | 0.0377 | - |
Nalpha-benzyloxycarbonyl-L-Lys-p-nitrophenyl ester | - |
Bos taurus | |
| 3.4.21.6 | 0.0867 | - |
benzoyl-Ile-Glu(piperidineamide)-Gly-Arg-p-nitroanilide | native enzyme | Bos taurus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.6 | Bos taurus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.21.6 | proteolytic modification | factor X is the zymogen | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.6 | blood plasma | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.6 | benzoyl-Ile-Glu(piperidineamide)-Gly-Arg-p-nitroanilide + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.6 | benzoyl-Ile-Glu-(-H/OMe)-Gly-Arg-p-nitroanilide + H2O | - |
Bos taurus | ? | - |
? | |
| 3.4.21.6 | Nalpha-benzyloxycarbonyl-L-Lys-4-nitrophenyl ester + H2O | - |
Bos taurus | Nalpha-benzyloxycarbonyl-L-Lys + 4-nitrophenol | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.6 | 2.17 | - |
Nalpha-benzyloxycarbonyl-L-Lys-p-nitrophenyl ester | - |
Bos taurus | |
| 3.4.21.6 | 145 | - |
benzoyl-Ile-Glu(piperidineamide)-Gly-Arg-p-nitroanilide | native enzyme | Bos taurus | |
| 3.4.21.6 | 146 | - |
benzoyl-Ile-Glu-(-H/OMe)-Gly-Arg-p-nitroanilide | native enzyme | Bos taurus | |
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