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Literature summary extracted from

  • Andrews, J.M.; Baillie, R.D.
    The enzymatic nature of human c1r: a subcomponent of the first component of complement (1979), J. Immunol., 123, 1403-1408.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.41 R463X the mutations Arg463Gln, Arg463Lys or Arg463Phe all stabilize the zymogen state Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.41 diisopropyl fluorophosphate
-
 Homo sapiens
3.4.21.41 additional information above 0.0005 mM C1rbar the enzyme aggregates with loss of activity Homo sapiens
3.4.21.41 p-amidinophenylmethylsulfonyl fluoride
-
 Homo sapiens
3.4.21.41 p-tosyl-Lys-chloromethyl ketone
-
 Homo sapiens
3.4.21.41 phenylmethylsulfonyl fluoride
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.41 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.41 N-acetyl-Arg methyl ester + H2O
-
 Homo sapiens N-acetyl-Arg + methanol
-
 ?
3.4.21.41 N-acetyl-Gly-Lys methyl ester + H2O
-
 Homo sapiens N-acetyl-Gly-Lys + methanol
-
 ?
3.4.21.41 N-carbobenzoxy-Lys-p-nitrophenyl ester + H2O
-
 Homo sapiens N-carbobenzoxy-Lys + 4-nitrophenyl
-
 ?
3.4.21.41 N-carbobenzoxy-Tyr-p-nitrophenyl ester + H2O
-
 Homo sapiens N-carbobenzoxy-Tyr + 4-nitrophenol
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.41 12.5
-
 N-Acetyl-Gly-Lys methyl ester
-
 Homo sapiens
3.4.21.41 18.3
-
 N-acetyl-Arg methyl ester
-
 Homo sapiens