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Literature summary extracted from

  • Schechter, N.M.; Jordan, L.M.; James, A.M.; Cooperman, B.S.; Wang, Z.; Rubin, H.
    Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus substrate properties (1993), J. Biol. Chem., 268, 23626-23633.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.39 0.06
-
 DRVWIHPFHL
-
 Homo sapiens
3.4.21.39 0.1
-
 succinyl-Val-Pro-Phe-4-nitroanilide
-
 Homo sapiens
3.4.21.39 0.11
-
 DRVWIHPWHL
-
 Homo sapiens
3.4.21.39 0.31
-
 DRVYIHPLHL
-
 Homo sapiens
3.4.21.39 0.398
-
 angiotensin I
-
 Homo sapiens
3.4.21.39 0.8
-
 succinyl-Ala-Ala-Pro-Phe-4-nitroanilide
-
 Homo sapiens
3.4.21.39 0.9
-
 succinyl-Val-Pro-Leu-4-nitroanilide
-
 Homo sapiens
3.4.21.39 1.2
-
 succinyl-Val-Pro-Met-4-nitroanilide
-
 Homo sapiens
3.4.21.39 2.6
-
 succinyl-Ala-Ala-Pro-Met-4-nitroanilide
-
 Homo sapiens
3.4.21.39 3
-
 succinyl-Ala-Ala-Pro-Leu-4-nitroanilide
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.39 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.39 mast cell
-
 Homo sapiens
-
3.4.21.39 skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.39 angiotensin I + H2O
-
 Homo sapiens angiotensin II + His-Leu
-
 ?
3.4.21.39 DRVWIHPFHL + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 DRVWIHPLHL + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 DRVWIHPWHL + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 succinyl-Ala-Ala-Pro-Leu-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 succinyl-Ala-Ala-Pro-Met-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 succinyl-Val-Pro-Leu-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 succinyl-Val-Pro-Met-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 succinyl-Val-Pro-Phe-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.39 succinyl-Val-Pro-Trp-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.39 2.5
-
 succinyl-Ala-Ala-Pro-Met-4-nitroanilide
-
 Homo sapiens
3.4.21.39 6.7
-
 succinyl-Ala-Ala-Pro-Leu-4-nitroanilide
-
 Homo sapiens
3.4.21.39 8.7
-
 succinyl-Val-Pro-Met-4-nitroanilide
-
 Homo sapiens
3.4.21.39 21
-
 succinyl-Val-Pro-Leu-4-nitroanilide
-
 Homo sapiens
3.4.21.39 46
-
 DRVYIHPLHL
-
 Homo sapiens
3.4.21.39 65
-
 succinyl-Ala-Ala-Pro-Phe-4-nitroanilide
-
 Homo sapiens
3.4.21.39 75
-
 succinyl-Val-Pro-Phe-4-nitroanilide
-
 Homo sapiens
3.4.21.39 160
-
 DRVWIHPFHL
-
 Homo sapiens
3.4.21.39 210
-
 DRVWIHPWHL
-
 Homo sapiens