BRENDA - Enzyme Database show

Inhibition of chymase activity by long chain fatty acids

Kido, H.; Fukusen, N.; Katunuma, N.; Arch. Biochem. Biophys. 230, 610-614 (1984)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.4.21.39
elaidic acid
-
Rattus norvegicus
3.4.21.39
fatty acids
carbon chain length of 14-22
Rattus norvegicus
3.4.21.39
linoleic acid
-
Rattus norvegicus
3.4.21.39
linolenic acid
-
Rattus norvegicus
3.4.21.39
oleic acid
reversible inhibitor
Rattus norvegicus
3.4.21.39
stearic acid
strong inhibition at pH 8.5-9.5, slight inhibition at pH 7.5, no inhibition at pH 6.0
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.4.21.39
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.4.21.39
tongue
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.4.21.39
apo-ornithine-aminotransferase + H2O
-
81363
Rattus norvegicus
?
-
-
-
?
3.4.21.39
Succinyl-Ala-Ala-Pro-Phe-4-methylcoumarin 7-amide + H2O
-
81363
Rattus norvegicus
?
-
-
-
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.4.21.39
7.5
9
hydrolysis of succinyl-Ala-Ala-Pro-Phe-4-methylcoumarin 7-amide
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.4.21.39
elaidic acid
-
Rattus norvegicus
3.4.21.39
fatty acids
carbon chain length of 14-22
Rattus norvegicus
3.4.21.39
linoleic acid
-
Rattus norvegicus
3.4.21.39
linolenic acid
-
Rattus norvegicus
3.4.21.39
oleic acid
reversible inhibitor
Rattus norvegicus
3.4.21.39
stearic acid
strong inhibition at pH 8.5-9.5, slight inhibition at pH 7.5, no inhibition at pH 6.0
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.4.21.39
tongue
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.4.21.39
apo-ornithine-aminotransferase + H2O
-
81363
Rattus norvegicus
?
-
-
-
?
3.4.21.39
Succinyl-Ala-Ala-Pro-Phe-4-methylcoumarin 7-amide + H2O
-
81363
Rattus norvegicus
?
-
-
-
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.4.21.39
7.5
9
hydrolysis of succinyl-Ala-Ala-Pro-Phe-4-methylcoumarin 7-amide
Rattus norvegicus