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Literature summary extracted from

  • Hooper, N.M.; Turner, A.J.
    Isolation of two differentially glycosylated forms of peptidyl-dipeptidase A (angiotensin converting enzyme) from pig brain: a re-evaluation of their role in neuropeptide metabolism (1987), Biochem. J., 241, 625-633.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 enalaprilate
-
 Sus scrofa
3.4.15.1 lisinopril
-
 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.15.1 170000
-
 x * 170000, one enzyme form from striatum, SDS-PAGE Sus scrofa
3.4.15.1 180000
-
 x * 180000, one enzyme form from striatum and kindey enzyme Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.15.1 side-chain modification the 180000 Da enzyme form contains approximately 17% carbohydrate Sus scrofa

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.15.1
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 brain striatum, 2 enzyme forms: MW 170000 Da and MW 180000 Da Sus scrofa
-
3.4.15.1 kidney one enzyme form of 180000 Da Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.15.1 1.766
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 angiotensin I + H2O
-
 Sus scrofa angiotensin II + His-Leu
-
 ?
3.4.15.1 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 + H2O primary cleavage of Phe8-Gly9 Sus scrofa Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly + Leu-Met-NH2
-
 ?
3.4.15.1 benzoyl-Gly-His-Leu + H2O
-
 Sus scrofa benzoyl-Gly + His-Leu
-
 ?
3.4.15.1 bradykinin + H2O
-
 Sus scrofa Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe
-
 ?
3.4.15.1 [D-Ala2,Leu5]enkephalin + H2O
-
 Sus scrofa Tyr-D-Ala-Gly + Phe-Leu
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.15.1 ? x * 180000, one enzyme form from striatum and kindey enzyme Sus scrofa
3.4.15.1 ? x * 170000, one enzyme form from striatum, SDS-PAGE Sus scrofa