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Literature summary extracted from
- Isolation and characterization of angiotensin converting enzyme from human kidney (1981), J. Biochem., 90, 1309-1319.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | 1,10-phenanthroline | - |
Homo sapiens |  |
| 3.4.15.1 | 2,3-dimercapto-1-propanol | - |
Homo sapiens | |
| 3.4.15.1 | 2-mercaptoethanol | - |
Homo sapiens | |
| 3.4.15.1 | 8-hydroxyquinoline | - |
Homo sapiens | |
| 3.4.15.1 | bradykinin potentiator C | - |
Homo sapiens | |
| 3.4.15.1 | captopril | - |
Homo sapiens | |
| 3.4.15.1 | dithiothreitol | - |
Homo sapiens | |
| 3.4.15.1 | EDTA | - |
Homo sapiens | |
| 3.4.15.1 | guanethidine | weak | Homo sapiens | |
| 3.4.15.1 | SDS | weak | Homo sapiens | |
| 3.4.15.1 | Teprotide | - |
Homo sapiens | |
| 3.4.15.1 | Urea | weak | Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.15.1 | 2 | - |
hippuryl-His-Leu | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.15.1 | membrane | - |
Homo sapiens | 16020 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | 170000 | - |
x * 170000, kidney, SDS-PAGE of the reduced enzyme | Homo sapiens |
| 3.4.15.1 | 199000 | - |
equilibrium sedimentation | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | side-chain modification | glycoprotein | Homo sapiens |
| 3.4.15.1 | side-chain modification | 13% neutral sugar | Homo sapiens |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.15.1 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | kidney | cortex | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | hippuryl-His-Leu + H2O | - |
Homo sapiens | hippuric acid + His-Leu | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | ? | x * 170000, kidney, SDS-PAGE of the reduced enzyme | Homo sapiens |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | 45 | - |
5-30 min, stable | Homo sapiens |
| 3.4.15.1 | 50 | - |
10 min, 60% loss of activity | Homo sapiens |
| 3.4.15.1 | 55 | - |
10 min, 80% loss of activity | Homo sapiens |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.15.1 | 545 | - |
hippuryl-His-Leu | - |
Homo sapiens | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | 8.2 | 8.4 | hydrolysis of hippuryl-His-Leu | Homo sapiens |
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