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Literature summary extracted from

  • Ondetti, M.A.; Cushman, D.W.
    Enzymes of the renin-angiotensin system and their inhibitors (1982), Annu. Rev. Biochem., 51, 283-308.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 additional information
-
Bos taurus
3.4.15.1 additional information
-
Canis lupus familiaris
3.4.15.1 additional information
-
Cavia porcellus
3.4.15.1 additional information
-
Homo sapiens
3.4.15.1 additional information
-
Oryctolagus cuniculus
3.4.15.1 additional information
-
Papio anubis
3.4.15.1 additional information
-
Rattus norvegicus
3.4.15.1 additional information
-
Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.15.1 Zinc
-
Homo sapiens
3.4.15.1 Zinc contains 0.8 gatom of zinc per mol of enzyme Oryctolagus cuniculus
3.4.15.1 Zinc contains 1.2 gatom of zinc per mol of enzyme Equus caballus
3.4.15.1 Zinc contains 0.9 gatom of zinc per mol of enzyme Canis lupus familiaris

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.15.1 113000
-
gel filtration Equus caballus
3.4.15.1 126000
-
x * 126000, enzyme from lung, SDS-PAGE with 7% acryl amide Bos taurus
3.4.15.1 130000
-
x * 130000, enzyme from lung, SDS-PAGE with 7% acryl amide Homo sapiens
3.4.15.1 139000
-
x * 139000, SDS-PAGE with 7% acryl amide Rattus norvegicus
3.4.15.1 139000
-
x * 139000, SDS-PAGE with 7% acryl amide Sus scrofa
3.4.15.1 140000
-
x * 140000, enzyme from plasma, SDS-PAGE with 7% acryl amide Homo sapiens
3.4.15.1 140000
-
x * 140000, enzyme from plasma, SDS-PAGE with 7% acryl amide Oryctolagus cuniculus
3.4.15.1 140000
-
x * 140000, enzyme from lung, SDS-PAGE with 7% acryl amide Oryctolagus cuniculus
3.4.15.1 140000
-
x * 140000, enzyme from lung, SDS-PAGE with 7% acryl amide Canis lupus familiaris
3.4.15.1 165000
-
x * 165000, SDS-PAGE with 5% acryl amide Homo sapiens
3.4.15.1 180000
-
-
Homo sapiens
3.4.15.1 180000
-
gel filtration Bos taurus
3.4.15.1 180000
-
x * 180000, enzyme from lung, SDS-PAGE with 5% acryl amide Oryctolagus cuniculus
3.4.15.1 195000
-
x * 195000, enzyme from kidney, SDS-PAGE with 5% acryl amide Sus scrofa
3.4.15.1 206000
-
x * 206000, enzyme from lung, SDS-PAGE with 5% acryl amide Sus scrofa
3.4.15.1 270000
-
gel filtration Rattus norvegicus
3.4.15.1 290000
-
enzyme from lung and protstate, gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Bos taurus
-
-
-
3.4.15.1 Canis lupus familiaris
-
-
-
3.4.15.1 Cavia porcellus
-
-
-
3.4.15.1 Equus caballus
-
-
-
3.4.15.1 Homo sapiens
-
-
-
3.4.15.1 Oryctolagus cuniculus
-
-
-
3.4.15.1 Papio anubis
-
baboon
-
3.4.15.1 Rattus norvegicus
-
-
-
3.4.15.1 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.15.1 side-chain modification glycoprotein Cavia porcellus
3.4.15.1 side-chain modification glycoprotein Homo sapiens
3.4.15.1 side-chain modification glycoprotein Rattus norvegicus
3.4.15.1 side-chain modification glycoprotein Sus scrofa
3.4.15.1 side-chain modification glycoprotein Bos taurus
3.4.15.1 side-chain modification glycoprotein Oryctolagus cuniculus
3.4.15.1 side-chain modification glycoprotein Canis lupus familiaris
3.4.15.1 side-chain modification lung enzyme contains 16-29% carbohydrate, enzyme from serum contains 32% carbohydrate Oryctolagus cuniculus
3.4.15.1 side-chain modification contains 17% carbohydrate Canis lupus familiaris
3.4.15.1 side-chain modification contains 8% carbohydrate Rattus norvegicus
3.4.15.1 side-chain modification contains 8% carbohydrate Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 kidney
-
Homo sapiens
-
3.4.15.1 kidney
-
Rattus norvegicus
-
3.4.15.1 kidney
-
Sus scrofa
-
3.4.15.1 kidney
-
Bos taurus
-
3.4.15.1 kidney
-
Oryctolagus cuniculus
-
3.4.15.1 lung
-
Cavia porcellus
-
3.4.15.1 lung
-
Homo sapiens
-
3.4.15.1 lung
-
Rattus norvegicus
-
3.4.15.1 lung
-
Sus scrofa
-
3.4.15.1 lung
-
Bos taurus
-
3.4.15.1 lung
-
Oryctolagus cuniculus
-
3.4.15.1 lung
-
Canis lupus familiaris
-
3.4.15.1 lung
-
Papio anubis
-
3.4.15.1 plasma
-
Homo sapiens
-
3.4.15.1 plasma
-
Sus scrofa
-
3.4.15.1 plasma
-
Equus caballus
-
3.4.15.1 prostate gland
-
Homo sapiens
-
3.4.15.1 semen
-
Homo sapiens
-
3.4.15.1 semen
-
Bos taurus
-
3.4.15.1 serum
-
Homo sapiens
-
3.4.15.1 serum
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 benzyloxycarbonyl-Phe-His-Leu + H2O
-
Bos taurus benzyloxycarbonyl-Phe + His-Leu
-
?
3.4.15.1 hippuryl-Gly-Gly + H2O
-
Homo sapiens hippuric acid + Gly-Gly
-
?
3.4.15.1 hippuryl-Gly-Gly + H2O
-
Sus scrofa hippuric acid + Gly-Gly
-
?
3.4.15.1 hippuryl-His-Leu + H2O
-
Cavia porcellus hippuric acid + His-Leu
-
?
3.4.15.1 hippuryl-His-Leu + H2O
-
Homo sapiens hippuric acid + His-Leu
-
?
3.4.15.1 hippuryl-His-Leu + H2O
-
Rattus norvegicus hippuric acid + His-Leu
-
?
3.4.15.1 hippuryl-His-Leu + H2O
-
Sus scrofa hippuric acid + His-Leu
-
?
3.4.15.1 hippuryl-His-Leu + H2O
-
Bos taurus hippuric acid + His-Leu
-
?
3.4.15.1 hippuryl-His-Leu + H2O
-
Oryctolagus cuniculus hippuric acid + His-Leu
-
?
3.4.15.1 hippuryl-His-Leu + H2O
-
Canis lupus familiaris hippuric acid + His-Leu
-
?
3.4.15.1 hippuryl-His-Leu + H2O
-
Papio anubis hippuric acid + His-Leu
-
?

Subunits

EC Number Subunits Comment Organism
3.4.15.1 ? x * 139000, SDS-PAGE with 7% acryl amide Rattus norvegicus
3.4.15.1 ? x * 139000, SDS-PAGE with 7% acryl amide Sus scrofa
3.4.15.1 ? x * 140000, enzyme from plasma, SDS-PAGE with 7% acryl amide Homo sapiens
3.4.15.1 ? x * 140000, enzyme from plasma, SDS-PAGE with 7% acryl amide Oryctolagus cuniculus
3.4.15.1 ? x * 180000, enzyme from lung, SDS-PAGE with 5% acryl amide Oryctolagus cuniculus
3.4.15.1 ? x * 195000, enzyme from kidney, SDS-PAGE with 5% acryl amide Sus scrofa
3.4.15.1 ? x * 206000, enzyme from lung, SDS-PAGE with 5% acryl amide Sus scrofa
3.4.15.1 ? x * 140000, enzyme from lung, SDS-PAGE with 7% acryl amide Oryctolagus cuniculus
3.4.15.1 ? x * 140000, enzyme from lung, SDS-PAGE with 7% acryl amide Canis lupus familiaris
3.4.15.1 ? x * 165000, SDS-PAGE with 5% acryl amide Homo sapiens
3.4.15.1 ? x * 130000, enzyme from lung, SDS-PAGE with 7% acryl amide Homo sapiens
3.4.15.1 ? x * 126000, enzyme from lung, SDS-PAGE with 7% acryl amide Bos taurus