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Literature summary extracted from

  • Wilkes, S.H.; Prescott, J.M.
    Stereospecificity of amino acid hydroxamate inhibition of aminopeptidases (1983), J. Biol. Chem., 258, 13517-13521.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.4.11.10 generally extremely stable Vibrio proteolyticus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.10 Amino acid hydroxamates
-
 Vibrio proteolyticus
3.4.11.10 D-Leu-hydroxamate Ki: 2 nM, L-isomer bound 150 times less tightly Vibrio proteolyticus
3.4.11.10 D-Val-hydroxamate Ki: 5 nM Vibrio proteolyticus
3.4.11.10 DL-Ala-hydroxamate Ki: 0.0055 mM Vibrio proteolyticus
3.4.11.10 DL-Phe-hydroxamate Ki: 0.0008 mM Vibrio proteolyticus
3.4.11.10 DL-Thr-hydroxamate Ki: 0.002 mM Vibrio proteolyticus
3.4.11.10 DL-Val-hydroxamate Ki: 10 nM Vibrio proteolyticus
3.4.11.10 L-Ala-hydroxamate Ki: 0.02 mM Vibrio proteolyticus
3.4.11.10 L-Phe-hydroxamate Ki: 0.0088 mM Vibrio proteolyticus
3.4.11.10 L-Thr-hydroxamate Ki: 0.066 mM Vibrio proteolyticus
3.4.11.10 L-Val-hydroxamate Ki: 0.0022 mM Vibrio proteolyticus
3.4.11.10 additional information inhibited to a greater extend by D- than by L-hydroxamates of amino acids and aliphatic acids, pH-dependent Vibrio proteolyticus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.11.10 Peptides + H2O Vibrio proteolyticus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.10 Vibrio proteolyticus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.10 Peptides + H2O
-
 Vibrio proteolyticus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.11.10 7.5
-
 assay at Vibrio proteolyticus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.11.10 0.000002
-
 D-Leu-hydroxamate L-isomer bound 150 times less tightly Vibrio proteolyticus
3.4.11.10 0.000005
-
 D-Val-hydroxamate
-
 Vibrio proteolyticus
3.4.11.10 0.00001
-
 DL-Val-hydroxamate
-
 Vibrio proteolyticus
3.4.11.10 0.0008
-
 DL-Phe-hydroxamate
-
 Vibrio proteolyticus
3.4.11.10 0.002
-
 DL-Thr-hydroxamate
-
 Vibrio proteolyticus
3.4.11.10 0.0022
-
 L-Thr-hydroxamate
-
 Vibrio proteolyticus
3.4.11.10 0.0055
-
 DL-Ala-hydroxamate
-
 Vibrio proteolyticus
3.4.11.10 0.0088
-
 L-Phe-hydroxamate
-
 Vibrio proteolyticus
3.4.11.10 0.02
-
 L-Ala-hydroxamate
-
 Vibrio proteolyticus
3.4.11.10 860
-
 L-Val-hydroxamate
-
 Vibrio proteolyticus