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Literature summary extracted from
- beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase of rat liver (1981), Biochim. Biophys. Acta, 666, 181-190.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.2.5 | 0.27 | - |
(S)-3-hydroxy-3-methylglutaryl-CoA | microsomal | Rattus norvegicus |  |
| 3.1.2.5 | 0.83 | - |
(S)-3-hydroxy-3-methylglutaryl-CoA | soluble enzyme | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.2.5 | cytosol | - |
Rattus norvegicus | 5829 | - |
| 3.1.2.5 | microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.2.5 | (S)-3-hydroxy-3-methylglutaryl-CoA + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.2.5 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.2.5 | liver | - |
Rattus norvegicus | - |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.1.2.5 | -15°C, crude enzyme, 2 days, 40% loss of activity | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.2.5 | (S)-3-hydroxy-3-methylglutaryl-CoA + H2O | - |
Rattus norvegicus | CoA + 3-hydroxy-3-methylglutarate | - |
? | |
| 3.1.2.5 | (S)-3-hydroxy-3-methylglutaryl-CoA + H2O | - |
Rattus norvegicus | ? | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.2.5 | 4 | - |
microsomal, 6 h stable | Rattus norvegicus |
| 3.1.2.5 | 20 | - |
without substrate, microsomal, 31% loss of activity after 15 min | Rattus norvegicus |
| 3.1.2.5 | 37 | - |
without substrate, cytoplasm, 25% loss of activity after 30 min, microsomal, 50% loss of activity after 5 min | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.2.5 | 7.6 | - |
microsomal | Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.2.5 | 6.5 | 8 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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