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Literature summary extracted from

  • Karasawa, K.; Yato, M.; Setaka, M.; Nojima, S.
    Purification and characterization of platelet-activating factor acetylhydrolase from peritoneal fluid obtained from guinea pigs after endotoxin shock (1994), J. Biochem., 116, 374-379.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.47 diisopropylfluorophosphate
-
 Cavia porcellus
3.1.1.47 p-bromophenacyl bromide
-
 Cavia porcellus
3.1.1.47 phenylmethylsulfonyl fluoride
-
 Cavia porcellus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.47 63000
-
 gel filtration Cavia porcellus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Cavia porcellus inactivation of the substrate which represents a wide variety of bioactivities, including hypotension, platelat activation, bronchoconstriction ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Cavia porcellus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.47
-
 Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 ascites
-
 Cavia porcellus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.47 20.3
-
-
 Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O i.e. PAF Cavia porcellus 1-hexadecyl-sn-glycerol-3-phosphocholine + acetate
-
 ?
3.1.1.47 1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O
-
 Cavia porcellus 1-hexadecyl-glycero-3-phosphocholine + glutarate
-
 ?
3.1.1.47 1-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O
-
 Cavia porcellus 1-hexadecyl-glycero-3-phosphocholine + succinate
-
 ?
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O inactivation of the substrate which represents a wide variety of bioactivities, including hypotension, platelat activation, bronchoconstriction Cavia porcellus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.47 monomer 1 * 63000, SDS-PAGE Cavia porcellus