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Literature summary extracted from

  • Ito, H.; Monobe, K.; Okubo, S.; Aoki, S.
    Identification of novel antimicrobial compounds targeting Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase using dual hierarchical in silico structure-based drug screening (2024), Molecules, 29, 1303.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.13.2.1 N-[4-([4-[(naphthalen-1-yl)sulfamoyl]phenyl]sulfamoyl)phenyl]acetamide
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.13.2.1 S-adenosyl-L-homocysteine + H2O Mycobacterium tuberculosis
-
 L-homocysteine + adenosine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Mycobacterium tuberculosis H37Rv
-
 L-homocysteine + adenosine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
3.13.2.1 Mycobacterium tuberculosis P9WGV3
-
-
3.13.2.1 Mycobacterium tuberculosis H37Rv P9WGV3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Mycobacterium tuberculosis L-homocysteine + adenosine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Mycobacterium tuberculosis H37Rv L-homocysteine + adenosine
-
 r

Synonyms

EC Number Synonyms Comment Organism
3.13.2.1 S-adenosyl-L-homocysteine hydrolase
-
 Mycobacterium tuberculosis
3.13.2.1 SAHH
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.13.2.1 0.0302
-
 at pH 7.0 and 37°C Mycobacterium tuberculosis N-[4-([4-[(naphthalen-1-yl)sulfamoyl]phenyl]sulfamoyl)phenyl]acetamide