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Literature summary extracted from

  • Porat, J.; Vakiloroayaei, A.; Remnant, B.; Talebi, M.; Cargill, T.; Bayfield, M.
    Crosstalk between the tRNA methyltransferase Trm1 and RNA chaperone La influences eukaryotic tRNA maturation (2023), J. Biol. Chem., 299, 105326.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.216 D201A loss of activity on both nuclear- and mitochondrial-encoded tRNAs Schizosaccharomyces pombe

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.216 mitochondrion targeting to nucleus or mitochondrion depends on alternate transcriptional start sites Schizosaccharomyces pombe 5739
-
2.1.1.216 nucleus targeting to nucleus or mitochondrion depends on alternate transcriptional start sites Schizosaccharomyces pombe 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.216 Schizosaccharomyces pombe Q9P804
-
-
2.1.1.216 Schizosaccharomyces pombe 972 Q9P804
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.216 2 S-adenosyl-L-methionine + guanine26 in tRNA
-
 Schizosaccharomyces pombe 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
 ?
2.1.1.216 2 S-adenosyl-L-methionine + guanine26 in tRNA
-
 Schizosaccharomyces pombe 972 2 S-adenosyl-L-homocysteine + N2-dimethylguanine26 in tRNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.216 Trm1
-
 Schizosaccharomyces pombe

General Information

EC Number General Information Comment Organism
2.1.1.216 physiological function wild-type and catalytic-dead Trm1 are active in an in vivo tRNA-mediated suppression assay and possess RNA strand annealing and dissociation activity in vitro. RNA chaperone La binding to nascent pre-tRNAs decreases Trm1 tRNA dimethylation in vivo and in vitro Schizosaccharomyces pombe