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Literature summary extracted from

  • Gong, X.; Boyer, J.B.; Gierlich, S.; Pozoga, M.; Weidenhausen, J.; Sinning, I.; Meinnel, T.; Giglione, C.; Wang, Y.; Hell, R.; Wirtz, M.
    HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana (2024), Cell Rep., 43, 113768.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.255 Arabidopsis thaliana Q8VZM1 and Q9FKI4 auxiliary subunit NAA15, Q9FKI4i.e. catalytic subunit NAA10
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.255 leaf HYPK stabilizes the core NatA specifically in the leaves of plants Arabidopsis thaliana
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Synonyms

EC Number Synonyms Comment Organism
2.3.1.255 AA15
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 Arabidopsis thaliana
2.3.1.255 At1g80410
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 Arabidopsis thaliana
2.3.1.255 At5g13780
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 Arabidopsis thaliana
2.3.1.255 NAA10
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 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
2.3.1.255 physiological function in Arabidopsis thaliana, the UBA domain of Huntingtin yeast partner K (HYPK) is vital for stabilizing the NatA complex in an organ-specific manner. The N terminus of HYPK, including helix alpha1, is critical for promoting NatA activity on substrates starting with various amino acids. Deleting 42 amino acids inside the HYPK N terminus causes substantial destabilization of the plant proteome and higher tolerance toward drought stress Arabidopsis thaliana