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Literature summary extracted from

  • Biteau, N.G.; Roy, V.; Lambry, J.C.; Becker, H.F.; Myllykallio, H.; Agrofoglio, L.A.
    Synthesis of acyclic nucleoside phosphonates targeting flavin-dependent thymidylate synthase in Mycobacterium tuberculosis (2021), Bioorg. Med. Chem., 46, 116351.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.148 (4-(6-methyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)phosphonic acid 0.2 mM, 26.2% inhibition Mycobacterium tuberculosis
2.1.1.148 (4-(7-(3-(3-hexylureido)prop-1-ynyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)phosphonic acid 0.2 mM, 31.8% inhibition Mycobacterium tuberculosis
2.1.1.148 (4-(7-methoxy-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)but-2-en-1-yl)phosphonic acid 0.2 mM, 26.4% inhibition Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.148 Mycobacterium tuberculosis P9WG57
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2.1.1.148 Mycobacterium tuberculosis H37Rv P9WG57
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