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Literature summary extracted from

  • Koryakov, D.E.
    Diversity and functional specialization of H3K9-specific histone methyltransferases (2024), Bioessays, 46, e2300163.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.355 F449Y mutation blocks the conversion of H3K9me2 into H3K9me3 Schizosaccharomyces pombe

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.355 nucleus
-
 Homo sapiens 5634
-
2.1.1.366 nucleus
-
 Caenorhabditis elegans 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Homo sapiens activity toward histones in chromatin. SUV39H1 trimethylates H3K9, thereby creating a binding site for HP1, which recruits SUV4-20H. This enzyme generates H4K20me3 using as a substrate the H4K20me1 generated by SET8. Consequently, SUV39H1 indirectly affects the methylation of H4K20 via two pathways: it modifies SET8, thereby enhancing its activity, and creates a site for the binding of SUV4-20H 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Drosophila melanogaster
-
 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.355 Drosophila melanogaster P45975
-
-
2.1.1.355 Homo sapiens O43463
-
-
2.1.1.355 Homo sapiens Q9H5I1
-
-
2.1.1.355 Mus musculus O54864
-
-
2.1.1.355 Mus musculus Q9EQQ0
-
-
2.1.1.355 Neurospora crassa Q8X225
-
-
2.1.1.355 Neurospora crassa DSM 1257 Q8X225
-
-
2.1.1.355 Schizosaccharomyces pombe O60016
-
-
2.1.1.355 Schizosaccharomyces pombe ATCC 24843 O60016
-
-
2.1.1.366 Caenorhabditis elegans G5EEU2
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.1.1.355 ubiquitination the Clr4 molecule contains many lysine residues that can be ubiquitinated. Without this modification at position K109, K110, K113, or K114, the enzyme can dimethylate but loses the ability to trimethylate H3K9 Schizosaccharomyces pombe

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 activity toward histones in chromatin. SUV39H1 trimethylates H3K9, thereby creating a binding site for HP1, which recruits SUV4-20H. This enzyme generates H4K20me3 using as a substrate the H4K20me1 generated by SET8. Consequently, SUV39H1 indirectly affects the methylation of H4K20 via two pathways: it modifies SET8, thereby enhancing its activity, and creates a site for the binding of SUV4-20H Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
-
 Drosophila melanogaster 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 activity toward histones in chromatin Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Su(var)3-9 is a di- and trimethyltransferase of H3K9 Drosophila melanogaster 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
2.1.1.355 additional information Clr4 automethylates lysines K455 and K472 Schizosaccharomyces pombe ?
-
-
2.1.1.355 additional information the enzyme also methylates the non-histone substrates SET8 and DOT1L Homo sapiens ?
-
-
2.1.1.355 additional information SUV39H2 is capable of automethylation. The enzyme also methylates the non-histone substrates LSD1 and SUV39H2 Homo sapiens ?
-
-
2.1.1.355 additional information Clr4 automethylates lysines K455 and K472 Schizosaccharomyces pombe ATCC 24843 ?
-
-

Synonyms

EC Number Synonyms Comment Organism
2.1.1.355 Clr4
-
 Schizosaccharomyces pombe
2.1.1.355 Dim-5
-
 Neurospora crassa
2.1.1.355 H3K9-specific histone methyltransferase
-
 Schizosaccharomyces pombe
2.1.1.355 H3K9-specific histone methyltransferase
-
 Neurospora crassa
2.1.1.355 H3K9-specific histone methyltransferase
-
 Homo sapiens
2.1.1.355 H3K9-specific histone methyltransferase
-
 Mus musculus
2.1.1.355 H3K9-specific histone methyltransferase
-
 Drosophila melanogaster
2.1.1.355 SU(VAR)3-9
-
 Drosophila melanogaster
2.1.1.355 SUV39H1
-
 Homo sapiens
2.1.1.355 SUV39H1
-
 Mus musculus
2.1.1.355 Suv39h2
-
 Homo sapiens
2.1.1.355 Suv39h2
-
 Mus musculus
2.1.1.366 H3K9-specific histone methyltransferase
-
 Caenorhabditis elegans
2.1.1.366 SET-25
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
2.1.1.355 malfunction deletion of the clr4 gene eliminates H3K9me2/me3 but not H3K9me1, indicating the presence of another protein capable of monomethylating H3K9 Schizosaccharomyces pombe
2.1.1.355 metabolism SUV39H1 trimethylates H3K9, thereby creating a binding site for HP1, which recruits SUV4-20H. This enzyme generates H4K20me3 using as a substrate the H4K20me1 generated by SET8. Consequently, SUV39H1 indirectly affects the methylation of H4K20 via two pathways: it modifies SET8, thereby enhancing its activity, and creates a site for the binding of SUV4-20H Homo sapiens