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Literature summary extracted from

  • Zhang, Y.; Yao, T.; Jiang, Y.; Li, H.; Yuan, W.; Li, W.
    Deciphering a cyclodipeptide synthase pathway encoding prenylated indole alkaloids in Streptomyces leeuwenhoekii (2021), Appl. Environ. Microbiol., 87, e02525.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.2.B23 expression in Streptomyces albus J1074 Streptomyces leeuwenhoekii

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.B23 Streptomyces leeuwenhoekii
-
-
-
2.3.2.B23 Streptomyces leeuwenhoekii NRRL B-24963
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.B23 L-tryptophanyl-tRNATrp + L-tryptophanyl-tRNATrp
-
 Streptomyces leeuwenhoekii 2 tRNATrp + cyclo(L-tryptophanyl-L-tryptophanyl)
-
 ?
2.3.2.B23 L-tryptophanyl-tRNATrp + L-tryptophanyl-tRNATrp
-
 Streptomyces leeuwenhoekii NRRL B-24963 2 tRNATrp + cyclo(L-tryptophanyl-L-tryptophanyl)
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.B23 SazA
-
 Streptomyces leeuwenhoekii

General Information

EC Number General Information Comment Organism
2.3.2.B23 physiological function expression of CDPS SazA and of SazB harboring fused domains: phytoene synthase-like prenyltransferase and methyltransferase, in Streptomyces albus J1074 leads to the production of four prenylated indole alkaloids, including streptoazines A to C. SazA catalyzes the formation of cyclo(L-Trp-L-Trp) Streptomyces leeuwenhoekii