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Literature summary extracted from

  • Pierson, E.; Haufroid, M.; Gosain, T.P.; Chopra, P.; Singh, R.; Wouters, J.
    Identification and repurposing of trisubstituted harmine derivatives as novel inhibitors of Mycobacterium tuberculosis phosphoserine phosphatase (2020), Molecules, 25, 415.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.3.3 analysis application of a malachite green-based phosphatase assay for screening of inhibitors Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.3 expression in Escherichia coli Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.3 1-methyl-7-(3-methylbutoxy)-2,9-bis(3-methylbutyl)-9H-pyrido[3,4-b]indol-2-ium bromide competitive, compound inhibits the growth of Mycobacterium tuberculosis Mycobacterium tuberculosis
3.1.3.3 7-(cyclohexylmethoxy)-9-(cyclohexylmethyl)-1-methyl-2-(2-cyclohexylethyl)-beta-carboline competitive, compound inhibits the growth of Mycobacterium tuberculosis Mycobacterium tuberculosis
3.1.3.3 7-(cyclohexylmethoxy)-9-(cyclohexylmethyl)-1-methyl-2-(2-phenylethyl)-9H-pyrido[3,4-b]indol-2-ium bromide competitive, compound inhibits the growth of Mycobacterium tuberculosis Mycobacterium tuberculosis
3.1.3.3 9-benzyl-7-(benzyloxy)-1-methyl-2-[2-(naphthalen-2-yl)ethyl]-9H-pyrido[3,4-b]indol-2-ium bromide competitive, compound inhibits the growth of Mycobacterium tuberculosis Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.3 Mycobacterium tuberculosis O53289
-
-
3.1.3.3 Mycobacterium tuberculosis H37Rv O53289
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.3 O-phospho-L-serine + H2O
-
 Mycobacterium tuberculosis L-serine + phosphate
-
 ?
3.1.3.3 O-phospho-L-serine + H2O
-
 Mycobacterium tuberculosis H37Rv L-serine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.3 SerB2
-
 Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.3.3 0.00175
-
 7-(cyclohexylmethoxy)-9-(cyclohexylmethyl)-1-methyl-2-(2-cyclohexylethyl)-beta-carboline pH 7.4, 37°C, Hill coefficient 1.78 Mycobacterium tuberculosis
3.1.3.3 0.00327
-
 7-(cyclohexylmethoxy)-9-(cyclohexylmethyl)-1-methyl-2-(2-phenylethyl)-9H-pyrido[3,4-b]indol-2-ium bromide pH 7.4, 37°C, Hill coefficient 2.39 Mycobacterium tuberculosis
3.1.3.3 0.00666
-
 9-benzyl-7-(benzyloxy)-1-methyl-2-[2-(naphthalen-2-yl)ethyl]-9H-pyrido[3,4-b]indol-2-ium bromide pH 7.4, 37°C, Hill coefficient 1.42 Mycobacterium tuberculosis
3.1.3.3 0.0183
-
 1-methyl-7-(3-methylbutoxy)-2,9-bis(3-methylbutyl)-9H-pyrido[3,4-b]indol-2-ium bromide pH 7.4, 37°C, Hill coefficient 1.45 Mycobacterium tuberculosis