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Literature summary extracted from

  • Li, H.X.; Heo, M.; Go, Y.; Kim, Y.S.; Kim, Y.H.; Yang, S.Y.; Li, W.
    Coumarin and moracin derivatives from mulberry leaves (Morus alba L.) with soluble epoxide hydrolase inhibitory activity (2020), Molecules, 25, 3967.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.10 aesculetin coumarin derivative from mulberry leaves, competitive Homo sapiens
3.3.2.10 moracin B isolated from mulberry leaves, competitive Homo sapiens
3.3.2.10 moracin J isolated from mulberry leaves, mixed type inhibitor Homo sapiens
3.3.2.10 moracin M isolated from mulberry leaves, mixed type inhibitor Homo sapiens
3.3.2.10 moracin M 3'-O-beta-glucopyranoside isolated from mulberry leaves, mixed-type inhibitor Homo sapiens
3.3.2.10 scopoletin coumarin derivative from mulberry leaves, competitive Homo sapiens
3.3.2.10 scopolin coumarin derivative from mulberry leaves, competitive Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.10 Homo sapiens P34913 cf. EC 3.1.3.76
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.3.2.10 0.0003
-
 scopoletin pH 7, temperature not specified in the publication Homo sapiens
3.3.2.10 0.001
-
 moracin B pH 7, temperature not specified in the publication Homo sapiens
3.3.2.10 0.0012
-
 aesculetin pH 7, temperature not specified in the publication Homo sapiens
3.3.2.10 0.0015
-
 moracin M pH 7, temperature not specified in the publication Homo sapiens
3.3.2.10 0.0021
-
 moracin J pH 7, temperature not specified in the publication Homo sapiens
3.3.2.10 0.0054
-
 scopolin pH 7, temperature not specified in the publication Homo sapiens
3.3.2.10 0.0058
-
 moracin M 3'-O-beta-glucopyranoside pH 7, temperature not specified in the publication Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.3.2.10 0.0002
-
 pH 7, temperature not specified in the publication Homo sapiens scopoletin
3.3.2.10 0.0011
-
 pH 7, temperature not specified in the publication Homo sapiens moracin B
3.3.2.10 0.0012
-
 pH 7, temperature not specified in the publication Homo sapiens moracin J
3.3.2.10 0.0069
-
 pH 7, temperature not specified in the publication Homo sapiens aesculetin
3.3.2.10 0.0077
-
 pH 7, temperature not specified in the publication Homo sapiens moracin M 3'-O-beta-glucopyranoside
3.3.2.10 0.0099
-
 pH 7, temperature not specified in the publication Homo sapiens moracin M
3.3.2.10 0.0159
-
 pH 7, temperature not specified in the publication Homo sapiens scopolin