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Literature summary extracted from

  • Miranda, P.H.S.; Lourenco, E.M.G.; Morais, A.M.S.; de Oliveira, P.I.C.; Silverio, P.S.S.N.; Jordao, A.K.; Barbosa, E.G.
    Molecular modeling of a series of dehydroquinate dehydratase type II inhibitors of Mycobacterium tuberculosis and design of new binders (2021), Mol. Divers., 25, 1-12.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.10 (1R,2R,4S,5R)-1,4,5-trihydroxy-2-[2-[3-(hydroxymethyl)phenyl]pyridin-4-yl]-3-oxocyclohexane-1-carboxylic acid
-
 Mycobacterium tuberculosis
4.2.1.10 (1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(4-[5-[(2R)-pyrrolidin-2-yl]-1H-1,2,4-triazol-3-yl]phenyl)cyclohexane-1-carboxylic acid
-
 Mycobacterium tuberculosis
4.2.1.10 (1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-[3-(piperazin-1-yl)quinolin-7-yl]cyclohexane-1-carboxylic acid
-
 Mycobacterium tuberculosis
4.2.1.10 (1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-[5-[(1R)-1,2,3,4-tetrahydroisoquinolin-1-yl]pyridin-3-yl]cyclohexane-1-carboxylic acid
-
 Mycobacterium tuberculosis
4.2.1.10 (1R,2R,4S,5R)-2-(2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl)-1,4,5-trihydroxy-3-oxocyclohexane-1-carboxylic acid
-
 Mycobacterium tuberculosis
4.2.1.10 6-[(1R,2R,4R,5S)-2-carboxy-2,4,5-trihydroxy-6-oxocyclohexyl]-7-fluoro-2-methylquinoline-4-carboxylic acid
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.10 3-dehydroquinate Mycobacterium tuberculosis
-
 3-dehydroshikimate + H2O
-
 ?
4.2.1.10 3-dehydroquinate Mycobacterium tuberculosis H37Rv
-
 3-dehydroshikimate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.10 Mycobacterium tuberculosis P9WPX7
-
-
4.2.1.10 Mycobacterium tuberculosis H37Rv P9WPX7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.10 3-dehydroquinate
-
 Mycobacterium tuberculosis 3-dehydroshikimate + H2O
-
 ?
4.2.1.10 3-dehydroquinate
-
 Mycobacterium tuberculosis H37Rv 3-dehydroshikimate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.10 dehydroquinate dehydratase II
-
 Mycobacterium tuberculosis
4.2.1.10 DHQase II
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
4.2.1.10 metabolism key enzyme of the shikimate pathway Mycobacterium tuberculosis