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Literature summary extracted from

  • Rorvik, G.H.; Liskiewicz, K.A.; Kryuchkov, F.; Naemi, A.O.; Aasheim, H.C.; Petersen, F.C.; Kuentziger, T.M.; Simm, R.
    Cyclic di-adenosine monophosphate regulates metabolism and growth in the oral commensal Streptococcus mitis (2020), Microorganisms, 8, 1269.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.60 expression in Escherichia coli Streptococcus mitis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.60 0.1485
-
 cyclic-di-3',5'-adenylate pH 8.5, 37°C Streptococcus mitis
3.1.4.60 0.877
-
 5'-O-phosphonoadenylyl-(3'->5')-adenosine pH 8.5, 37°C Streptococcus mitis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.60 92000
-
 gel filtration Streptococcus mitis

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.60 Streptococcus mitis
-
-
-
3.1.4.60 Streptococcus mitis CCUG 31611
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.60
-
 Streptococcus mitis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.60 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O
-
 Streptococcus mitis 2 AMP
-
 ?
3.1.4.60 5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O
-
 Streptococcus mitis CCUG 31611 2 AMP
-
 ?
3.1.4.60 cyclic-di-3',5'-adenylate + H2O
-
 Streptococcus mitis 2 AMP
-
 ?
3.1.4.60 cyclic-di-3',5'-adenylate + H2O
-
 Streptococcus mitis CCUG 31611 2 AMP
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.60 dimer
-
 Streptococcus mitis

Synonyms

EC Number Synonyms Comment Organism
3.1.4.60 PDE2
-
 Streptococcus mitis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.4.60 0.078
-
 cyclic-di-3',5'-adenylate pH 8.5, 37°C Streptococcus mitis
3.1.4.60 3527
-
 5'-O-phosphonoadenylyl-(3'->5')-adenosine pH 8.5, 37°C Streptococcus mitis

General Information

EC Number General Information Comment Organism
3.1.4.60 malfunction the DELTApde2-mutant grows significantly slower in exponential phase compared to the wild-type and reaches a lower OD in stationary phase. Thes display a reduced rate of glucose metabolism Streptococcus mitis

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.1.4.60 0.525
-
 cyclic-di-3',5'-adenylate pH 8.5, 37°C Streptococcus mitis
3.1.4.60 4021
-
 5'-O-phosphonoadenylyl-(3'->5')-adenosine pH 8.5, 37°C Streptococcus mitis