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Literature summary extracted from

  • Tiwari, P.; Gosain, T.P.; Chugh, S.; Singh, M.; Sankhe, G.D.; Arora, G.; Kidwai, S.; Agarwal, S.; Saini, D.K.; Singh, R.
    Exopolyphosphatases PPX1 and PPX2 from Mycobacterium tuberculosis regulate dormancy response and pathogenesis (2022), Microb. Pathog., 173, 105885.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.11 expressed and purified as MBP fusion proteins from Escherichia coli Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.11 Mg2+ required Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.11 Mycobacterium tuberculosis P9WHV5
-
-
3.6.1.11 Mycobacterium tuberculosis P96374
-
-
3.6.1.11 Mycobacterium tuberculosis H37Rv P9WHV5
-
-
3.6.1.11 Mycobacterium tuberculosis H37Rv P96374
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.11 additional information both PPX1 and PPX2 also display GTPase and ATPase activity in vitro Mycobacterium tuberculosis ?
-
-
3.6.1.11 additional information both PPX1 and PPX2 also display GTPase and ATPase activity in vitro Mycobacterium tuberculosis H37Rv ?
-
-
3.6.1.11 polyP17 + H2O
-
 Mycobacterium tuberculosis polyP16 + phosphate
-
 ?
3.6.1.11 polyP17 + H2O
-
 Mycobacterium tuberculosis H37Rv polyP16 + phosphate
-
 ?
3.6.1.11 triphosphate + H2O
-
 Mycobacterium tuberculosis diphosphate + phosphate
-
 ?
3.6.1.11 triphosphate + H2O
-
 Mycobacterium tuberculosis H37Rv diphosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.11 Rv0496
-
 Mycobacterium tuberculosis
3.6.1.11 Rv1026
-
 Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.11 7 8
-
 Mycobacterium tuberculosis

Expression

EC Number Organism Comment Expression
3.6.1.11 Mycobacterium tuberculosis expression is increased by about 10fold, in low oxygen growth conditions up
3.6.1.11 Mycobacterium tuberculosis expression is increased by about 25fold, in low oxygen growth conditions up

General Information

EC Number General Information Comment Organism
3.6.1.11 physiological function simultaneous deletion of both PPX1 and PPX2 strain leads to compromised biofilm formation and results in the suppression of the expression of dormancy-associated genes. Both PPX1 and PPX2 enzymes are important for Mycobacterium tuberculosis to establish infection in guinea pigs Mycobacterium tuberculosis