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Literature summary extracted from

  • Maitra, A.; Nukala, S.; Dickman, R.; Martin, L.; Munshi, T.; Gupta, A.; Shepherd, A.; Arnvig, K.; Tabor, A.; Keep, N.; Bhakta, S.
    Characterization of the MurT/GatD complex in Mycobacterium tuberculosis towards validating a novel anti-tubercular drug target (2021), JAC Antimicrob. Resist., 3, dlab028.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
6.3.5.13 G61A mutation of the P-loop/Walker A motif of subunit MurT, the inorganic phosphate release is reduced Mycobacterium tuberculosis
6.3.5.13 S63A mutation of the P-loop/Walker A motif of subunit MurT, the inorganic phosphate release is reduced Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.13 Mycobacterium tuberculosis I6Y4C7 and I6XI14 I6Y4C7 i.e. subunit MurT, I6XI14 i.e. subunit GatD
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6.3.5.13 Mycobacterium tuberculosis H37Rv I6Y4C7 and I6XI14 I6Y4C7 i.e. subunit MurT, I6XI14 i.e. subunit GatD
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.13 additional information under comparable conditions, Rv3712 exhibits 1/50th of the ATPase activity of mycobacterial Mur ligases Mycobacterium tuberculosis ?
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-
6.3.5.13 additional information under comparable conditions, Rv3712 exhibits 1/50th of the ATPase activity of mycobacterial Mur ligases Mycobacterium tuberculosis H37Rv ?
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-

Synonyms

EC Number Synonyms Comment Organism
6.3.5.13 GatD
-
 Mycobacterium tuberculosis
6.3.5.13 MurT
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 Mycobacterium tuberculosis
6.3.5.13 Rv3712
-
 Mycobacterium tuberculosis
6.3.5.13 Rv3713
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
6.3.5.13 physiological function MurT interacts with GatD and forms an interaction network with proteins involved in cell regulation and cell division. Heterologous coexpression in Mycobacterium bovis BCG produces bacilli that are significantly shorter and thicker Mycobacterium tuberculosis