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Literature summary extracted from

  • Isa, M.A.
    Homology modeling and molecular dynamic simulation of UDP-N-acetylmuramoyl-L-alanine-D-glutamate ligase (MurD) from Mycobacterium tuberculosis H37Rv using in silico approach (2019), Comput. Biol. Chem., 78, 116-126.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.9 6-bromo-2-(4-ethoxyphenyl)quinoline-4-carboxylic acid
-
 Mycobacterium tuberculosis
6.3.2.9 aminothiazole
-
 Mycobacterium tuberculosis
6.3.2.9 ATP substrate inhibition Mycobacterium tuberculosis
6.3.2.9 strophanthidin i.e. PubChem6185 Mycobacterium tuberculosis
6.3.2.9 ZINC11881196
-
 Mycobacterium tuberculosis
6.3.2.9 ZINC12247644
-
 Mycobacterium tuberculosis
6.3.2.9 ZINC14995379
-
 Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.2.9 cytoplasm
-
 Mycobacterium tuberculosis 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.9 ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate Mycobacterium tuberculosis
-
 ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
-
 ?
6.3.2.9 ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate Mycobacterium tuberculosis H37Rv
-
 ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.9 Mycobacterium tuberculosis P9WJL5
-
-
6.3.2.9 Mycobacterium tuberculosis H37Rv P9WJL5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.9 ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate
-
 Mycobacterium tuberculosis ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
-
 ?
6.3.2.9 ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate
-
 Mycobacterium tuberculosis H37Rv ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.2.9 monomer 1 * 49300, calculated from amino acid sequence Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
6.3.2.9 MurD
-
 Mycobacterium tuberculosis