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Literature summary extracted from
- Discovery of inhibitors of the lipopolysaccharide transporter MsbA From a screening hit to potent wild-type Gram-negative activity (2022), J. Med. Chem., 65, 4085-4120.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 7.5.2.5 | enzyme in complex with inhibitors (S,E)-3-(7-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-1-methylnaphthalen-2-yl)acrylic acid or (S,E)-3-(6-(1-(3-amino-2,6-dichlorophenyl)ethoxy)-4-cyclopropylquinolin-3-yl)acrylic acid, hanging drop vapor diffusion method | Enterobacter cloacae |
| 7.5.2.5 | enzyme in complex with inhibitors (S,E)-3-(7-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-1-methylnaphthalen-2-yl)acrylic acid or (S,E)-3-(6-(1-(3-amino-2,6-dichlorophenyl)ethoxy)-4-cyclopropylquinolin-3-yl)acrylic acid, hanging drop vapor diffusion method | Escherichia coli |
| 7.5.2.5 | enzyme in complex with inhibitors (S,E)-3-(7-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-1-methylnaphthalen-2-yl)acrylic acid or (S,E)-3-(6-(1-(3-amino-2,6-dichlorophenyl)ethoxy)-4-cyclopropylquinolin-3-yl)acrylic acid, hanging drop vapor diffusion method | Klebsiella pneumoniae |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.5.2.5 | (2E)-3-[1-cyclopropyl-7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-oxo-1,4-dihydroquinazolin-2-yl]prop-2-enoic acid | - |
Enterobacter cloacae |  |
| 7.5.2.5 | (2E)-3-[1-cyclopropyl-7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-oxo-1,4-dihydroquinazolin-2-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[1-cyclopropyl-7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-oxo-1,4-dihydroquinazolin-2-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[2-(cyclopropylmethyl)-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[2-(cyclopropylmethyl)-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[2-(cyclopropylmethyl)-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-cyano-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-cyano-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-cyano-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1R)-1-(2,6-dichlorophenyl)-2-hydroxyethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1R)-1-(2,6-dichlorophenyl)-2-hydroxyethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1R)-1-(2,6-dichlorophenyl)-2-hydroxyethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(1,4-dimethyl-1H-pyrazol-5-yl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(1,4-dimethyl-1H-pyrazol-5-yl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(1,4-dimethyl-1H-pyrazol-5-yl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,4-dichloropyridin-3-yl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,4-dichloropyridin-3-yl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,4-dichloropyridin-3-yl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-oxo-1lambda5-quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-oxo-1lambda5-quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-oxo-1lambda5-quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-8-(hydroxymethyl)quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-8-(hydroxymethyl)quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-8-(hydroxymethyl)quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]cinnolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]cinnolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]cinnolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]-N-(methanesulfonyl)prop-2-enamide | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]-N-(methanesulfonyl)prop-2-enamide | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]-N-(methanesulfonyl)prop-2-enamide | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enamide | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enamide | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enamide | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(propan-2-yl)oxy]quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(propan-2-yl)oxy]quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-cyclopropyl-6-[(propan-2-yl)oxy]quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-2-methylphenyl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-2-methylphenyl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-2-methylphenyl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[5-cyclopropyl-3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1,7-naphthyridin-6-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[5-cyclopropyl-3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1,7-naphthyridin-6-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[5-cyclopropyl-3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1,7-naphthyridin-6-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[6-(1-cyclohexylethoxy)-4-cyclopropylquinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[6-(1-cyclohexylethoxy)-4-cyclopropylquinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[6-(1-cyclohexylethoxy)-4-cyclopropylquinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(1H-imidazol-1-yl)quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(1H-imidazol-1-yl)quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(1H-imidazol-1-yl)quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(difluoromethyl)quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(difluoromethyl)quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(difluoromethyl)quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(dimethylamino)quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(dimethylamino)quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(dimethylamino)quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(fluoromethyl)quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(fluoromethyl)quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(fluoromethyl)quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(oxetan-3-yl)quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(oxetan-3-yl)quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(oxetan-3-yl)quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-hydroxyquinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-hydroxyquinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-hydroxyquinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-methylquinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-methylquinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-methylquinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(3-amino-2,6-dichlorophenyl)ethoxy]-4-cyclopropylquinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(3-amino-2,6-dichlorophenyl)ethoxy]-4-cyclopropylquinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[6-[(1S)-1-(3-amino-2,6-dichlorophenyl)ethoxy]-4-cyclopropylquinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[6-[1-(2-chloro-6-cyanophenyl)ethoxy]-4-cyclopropylquinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[6-[1-(2-chloro-6-cyanophenyl)ethoxy]-4-cyclopropylquinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[6-[1-(2-chloro-6-cyanophenyl)ethoxy]-4-cyclopropylquinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-methylnaphthalen-2-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-methylnaphthalen-2-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-methylnaphthalen-2-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[8-(cyanomethyl)-4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[8-(cyanomethyl)-4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[8-(cyanomethyl)-4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (2E)-3-[8-borono-4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (2E)-3-[8-borono-4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Escherichia coli | |
| 7.5.2.5 | (2E)-3-[8-borono-4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (3R,4R)-4-amino-1-[(2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoyl]piperidine-3-carboxylic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (3R,4R)-4-amino-1-[(2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoyl]piperidine-3-carboxylic acid | - |
Escherichia coli | |
| 7.5.2.5 | (3R,4R)-4-amino-1-[(2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoyl]piperidine-3-carboxylic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | (E)-2-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]ethene-1-sulfonic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | (E)-2-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]ethene-1-sulfonic acid | - |
Escherichia coli | |
| 7.5.2.5 | (E)-2-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]ethene-1-sulfonic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 1,3-dichloro-2-[(1S)-1-(3-cyclopropylphenoxy)ethyl]-4-fluorobenzene | - |
Enterobacter cloacae | |
| 7.5.2.5 | 1,3-dichloro-2-[(1S)-1-(3-cyclopropylphenoxy)ethyl]-4-fluorobenzene | - |
Escherichia coli | |
| 7.5.2.5 | 1,3-dichloro-2-[(1S)-1-(3-cyclopropylphenoxy)ethyl]-4-fluorobenzene | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 2-(cyclopropyl[4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyrimidin-2-yl]amino)-1,3-thiazole-4-carboxylic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | 2-(cyclopropyl[4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyrimidin-2-yl]amino)-1,3-thiazole-4-carboxylic acid | - |
Escherichia coli | |
| 7.5.2.5 | 2-(cyclopropyl[4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyrimidin-2-yl]amino)-1,3-thiazole-4-carboxylic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridine | - |
Enterobacter cloacae | |
| 7.5.2.5 | 2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridine | - |
Escherichia coli | |
| 7.5.2.5 | 2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridine | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyrimidine | - |
Enterobacter cloacae | |
| 7.5.2.5 | 2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyrimidine | - |
Escherichia coli | |
| 7.5.2.5 | 2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyrimidine | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 2-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridine | - |
Enterobacter cloacae | |
| 7.5.2.5 | 2-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridine | - |
Escherichia coli | |
| 7.5.2.5 | 2-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridine | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 3-(3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]-1H-pyrazol-1-yl)propanoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | 3-(3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]-1H-pyrazol-1-yl)propanoic acid | - |
Escherichia coli | |
| 7.5.2.5 | 3-(3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]-1H-pyrazol-1-yl)propanoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 3-([2-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]amino)-3-oxopropanoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | 3-([2-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]amino)-3-oxopropanoic acid | - |
Escherichia coli | |
| 7.5.2.5 | 3-([2-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]amino)-3-oxopropanoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 3-[2-(2-aminoethoxy)-4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]propanoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | 3-[2-(2-aminoethoxy)-4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]propanoic acid | - |
Escherichia coli | |
| 7.5.2.5 | 3-[2-(2-aminoethoxy)-4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]propanoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 3-[2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]anilino]-3-oxopropanoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | 3-[2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]anilino]-3-oxopropanoic acid | - |
Escherichia coli | |
| 7.5.2.5 | 3-[2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]anilino]-3-oxopropanoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]propanoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | 3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]propanoic acid | - |
Escherichia coli | |
| 7.5.2.5 | 3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]propanoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 3-[7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3,4-dihydroisoquinolin-2(1H)-yl]propanoic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | 3-[7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3,4-dihydroisoquinolin-2(1H)-yl]propanoic acid | - |
Escherichia coli | |
| 7.5.2.5 | 3-[7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3,4-dihydroisoquinolin-2(1H)-yl]propanoic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 3-[[(2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoyl]amino]pentanedioic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | 3-[[(2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoyl]amino]pentanedioic acid | - |
Escherichia coli | |
| 7.5.2.5 | 3-[[(2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoyl]amino]pentanedioic acid | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | - |
Enterobacter cloacae | |
| 7.5.2.5 | 4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | - |
Escherichia coli | |
| 7.5.2.5 | 4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-ol | - |
Enterobacter cloacae | |
| 7.5.2.5 | 4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-ol | - |
Escherichia coli | |
| 7.5.2.5 | 4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-ol | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 4-cyclopropyl-6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | - |
Enterobacter cloacae | |
| 7.5.2.5 | 4-cyclopropyl-6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | - |
Escherichia coli | |
| 7.5.2.5 | 4-cyclopropyl-6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | 6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]-4-(difluoromethyl)-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | - |
Enterobacter cloacae | |
| 7.5.2.5 | 6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]-4-(difluoromethyl)-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | - |
Escherichia coli | |
| 7.5.2.5 | 6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]-4-(difluoromethyl)-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | N1-[2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]propanediamide | - |
Enterobacter cloacae | |
| 7.5.2.5 | N1-[2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]propanediamide | - |
Escherichia coli | |
| 7.5.2.5 | N1-[2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]propanediamide | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | N1-[2-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]propanediamide | - |
Enterobacter cloacae | |
| 7.5.2.5 | N1-[2-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]propanediamide | - |
Escherichia coli | |
| 7.5.2.5 | N1-[2-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]propanediamide | - |
Klebsiella pneumoniae | |
| 7.5.2.5 | [4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinoline-3-sulfonyl]acetic acid | - |
Enterobacter cloacae | |
| 7.5.2.5 | [4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinoline-3-sulfonyl]acetic acid | - |
Escherichia coli | |
| 7.5.2.5 | [4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinoline-3-sulfonyl]acetic acid | - |
Klebsiella pneumoniae | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.5.2.5 | inner membrane | - |
Enterobacter cloacae | - |
- |
| 7.5.2.5 | inner membrane | - |
Escherichia coli | - |
- |
| 7.5.2.5 | inner membrane | - |
Klebsiella pneumoniae | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.5.2.5 | ATP + H2O + lipopolysaccharide[side 1] | Enterobacter cloacae | - |
ADP + phosphate + lipopolysaccharide[side 2] | - |
? | |
| 7.5.2.5 | ATP + H2O + lipopolysaccharide[side 1] | Escherichia coli | - |
ADP + phosphate + lipopolysaccharide[side 2] | - |
? | |
| 7.5.2.5 | ATP + H2O + lipopolysaccharide[side 1] | Klebsiella pneumoniae | - |
ADP + phosphate + lipopolysaccharide[side 2] | - |
? | |
| 7.5.2.5 | ATP + H2O + lipopolysaccharide[side 1] | Klebsiella pneumoniae ATCC 700721 | - |
ADP + phosphate + lipopolysaccharide[side 2] | - |
? | |
| 7.5.2.5 | ATP + H2O + lipopolysaccharide[side 1] | Enterobacter cloacae ATCC 13047 | - |
ADP + phosphate + lipopolysaccharide[side 2] | - |
? | |
| 7.5.2.5 | ATP + H2O + lipopolysaccharide[side 1] | Escherichia coli ATCC 700928 | - |
ADP + phosphate + lipopolysaccharide[side 2] | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.5.2.5 | Enterobacter cloacae | - |
- |
- |
| 7.5.2.5 | Enterobacter cloacae ATCC 13047 | - |
- |
- |
| 7.5.2.5 | Escherichia coli | - |
- |
- |
| 7.5.2.5 | Escherichia coli ATCC 700928 | - |
- |
- |
| 7.5.2.5 | Klebsiella pneumoniae | - |
- |
- |
| 7.5.2.5 | Klebsiella pneumoniae ATCC 700721 | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.5.2.5 | ATP + H2O + lipopolysaccharide[side 1] | - |
Enterobacter cloacae | ADP + phosphate + lipopolysaccharide[side 2] | - |
? | |
| 7.5.2.5 | ATP + H2O + lipopolysaccharide[side 1] | - |
Escherichia coli | ADP + phosphate + lipopolysaccharide[side 2] | - |
? | |
| 7.5.2.5 | ATP + H2O + lipopolysaccharide[side 1] | - |
Klebsiella pneumoniae | ADP + phosphate + lipopolysaccharide[side 2] | - |
? | |
| 7.5.2.5 | ATP + H2O + lipopolysaccharide[side 1] | - |
Klebsiella pneumoniae ATCC 700721 | ADP + phosphate + lipopolysaccharide[side 2] | - |
? | |
| 7.5.2.5 | ATP + H2O + lipopolysaccharide[side 1] | - |
Enterobacter cloacae ATCC 13047 | ADP + phosphate + lipopolysaccharide[side 2] | - |
? | |
| 7.5.2.5 | ATP + H2O + lipopolysaccharide[side 1] | - |
Escherichia coli ATCC 700928 | ADP + phosphate + lipopolysaccharide[side 2] | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.5.2.5 | MsbA | - |
Enterobacter cloacae |
| 7.5.2.5 | MsbA | - |
Escherichia coli |
| 7.5.2.5 | MsbA | - |
Klebsiella pneumoniae |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 7.5.2.5 | 0.000002 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.000002 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]-N-(methanesulfonyl)prop-2-enamide | |
| 7.5.2.5 | 0.000002 | - |
at pH 7.5 and 25°C | Escherichia coli | 4-cyclopropyl-6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | |
| 7.5.2.5 | 0.000003 | - |
at pH 7.5 and 25°C | Escherichia coli | 4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | |
| 7.5.2.5 | 0.000003 | - |
at pH 7.5 and 25°C | Escherichia coli | 6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]-4-(difluoromethyl)-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | |
| 7.5.2.5 | 0.000004 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.000005 | - |
at pH 7.5 and 25°C | Escherichia coli | (3R,4R)-4-amino-1-[(2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoyl]piperidine-3-carboxylic acid | |
| 7.5.2.5 | 0.000006 | - |
at pH 7.5 and 25°C | Escherichia coli | 3-(3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]-1H-pyrazol-1-yl)propanoic acid | |
| 7.5.2.5 | 0.000007 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enamide | |
| 7.5.2.5 | 0.000007 | - |
at pH 7.5 and 25°C | Escherichia coli | 3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]propanoic acid | |
| 7.5.2.5 | 0.000008 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(difluoromethyl)quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.000008 | - |
at pH 7.5 and 25°C | Escherichia coli | 6-[(1S)-1-(2,6-dichlorophenyl)ethoxy]-4-(difluoromethyl)-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]quinoline | |
| 7.5.2.5 | 0.000009 | - |
at pH 7.5 and 25°C | Escherichia coli | 3-[[(2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoyl]amino]pentanedioic acid | |
| 7.5.2.5 | 0.00001 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-8-(hydroxymethyl)quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.000012 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[5-cyclopropyl-3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1,7-naphthyridin-6-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.000012 | - |
at pH 7.5 and 25°C | Escherichia coli | 3-([2-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]amino)-3-oxopropanoic acid | |
| 7.5.2.5 | 0.000013 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-oxo-1lambda5-quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.000014 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[6-[(1S)-1-(3-amino-2,6-dichlorophenyl)ethoxy]-4-cyclopropylquinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.000014 | - |
at pH 7.5 and 25°C | Escherichia coli | (E)-2-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]ethene-1-sulfonic acid | |
| 7.5.2.5 | 0.000018 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,4-dichloropyridin-3-yl)ethoxy]quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.00002 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-methylquinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.00002 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]cinnolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.00002 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[8-(cyanomethyl)-4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.000024 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[6-[1-(2-chloro-6-cyanophenyl)ethoxy]-4-cyclopropylquinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.000025 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(fluoromethyl)quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.000027 | - |
at pH 7.5 and 25°C | Escherichia coli | N1-[2-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]propanediamide | |
| 7.5.2.5 | 0.000032 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1-methylnaphthalen-2-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.000032 | - |
at pH 7.5 and 25°C | Escherichia coli | 3-[2-(2-aminoethoxy)-4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]propanoic acid | |
| 7.5.2.5 | 0.00004 | - |
at pH 7.5 and 25°C | Escherichia coli | N1-[2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]propanediamide | |
| 7.5.2.5 | 0.000042 | - |
at pH 7.5 and 25°C | Escherichia coli | 4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-ol | |
| 7.5.2.5 | 0.000046 | - |
at pH 7.5 and 25°C | Escherichia coli | 2-(cyclopropyl[4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyrimidin-2-yl]amino)-1,3-thiazole-4-carboxylic acid | |
| 7.5.2.5 | 0.00006 | - |
at pH 7.5 and 25°C | Escherichia coli | 3-[2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]anilino]-3-oxopropanoic acid | |
| 7.5.2.5 | 0.000078 | - |
at pH 7.5 and 25°C | Escherichia coli | [4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinoline-3-sulfonyl]acetic acid | |
| 7.5.2.5 | 0.0001 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]prop-2-enoic acid | |
| 7.5.2.5 | 0.00011 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-cyano-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.00012 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(oxetan-3-yl)quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.00014 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.00015 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[8-borono-4-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.00029 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(dimethylamino)quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.00045 | - |
at pH 7.5 and 25°C | Escherichia coli | 2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyrimidine | |
| 7.5.2.5 | 0.00046 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[2-(cyclopropylmethyl)-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]prop-2-enoic acid | |
| 7.5.2.5 | 0.00055 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-cyclopropyl-6-[(1R)-1-(2,6-dichlorophenyl)-2-hydroxyethoxy]quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.0022 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-(1H-imidazol-1-yl)quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.0022 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-2-methylphenyl]prop-2-enoic acid | |
| 7.5.2.5 | 0.0034 | - |
at pH 7.5 and 25°C | Escherichia coli | 2-cyclopropyl-4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridine | |
| 7.5.2.5 | 0.005 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-hydroxyquinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.0058 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]phenyl]prop-2-enoic acid | |
| 7.5.2.5 | 0.0072 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[1-cyclopropyl-7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-4-oxo-1,4-dihydroquinazolin-2-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.01 | - |
IC50 above 0.01 mM, at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-cyclopropyl-6-[(propan-2-yl)oxy]quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.01 | - |
IC50 above 0.01 mM, at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[4-cyclopropyl-6-[(1S)-1-(1,4-dimethyl-1H-pyrazol-5-yl)ethoxy]quinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.01 | - |
IC50 above 0.01 mM, at pH 7.5 and 25°C | Escherichia coli | 1,3-dichloro-2-[(1S)-1-(3-cyclopropylphenoxy)ethyl]-4-fluorobenzene | |
| 7.5.2.5 | 0.01 | - |
IC50 above 0.01 mM, at pH 7.5 and 25°C | Escherichia coli | 2-cyclopropyl-6-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridine | |
| 7.5.2.5 | 0.039 | - |
at pH 7.5 and 25°C | Escherichia coli | (2E)-3-[6-(1-cyclohexylethoxy)-4-cyclopropylquinolin-3-yl]prop-2-enoic acid | |
| 7.5.2.5 | 0.05 | - |
IC50 above 0.05 mM, at pH 7.5 and 25°C | Escherichia coli | 3-[7-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3,4-dihydroisoquinolin-2(1H)-yl]propanoic acid | |
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