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Literature summary extracted from

  • Prasasty, V.D.; Cindana, S.; Ivan, F.X.; Zahroh, H.; Sinaga, E.
    Structure-based discovery of novel inhibitors of Mycobacterium tuberculosis CYP121 from Indonesian natural products (2020), Comput. Biol. Chem., 85, 107205.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.70 (1S,3R,4S,5S)-2-(3-amino-4,5-dihydro-3H-pyrazol-4-yl)-5-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1-hydroxy-3,4-dimethylcyclohexane-1-carboxylic acid
-
 Mycobacterium tuberculosis
1.14.19.70 (2E)-3-(5,6-dihydroxy-4'-methylbiphenyl-2-yl)prop-2-enoic acid
-
 Mycobacterium tuberculosis
1.14.19.70 (2R,3R)-8-(3-hydroxycyclohexyl)-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol
-
 Mycobacterium tuberculosis
1.14.19.70 2-(2-amino,4-hydroxy3-methylphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside a derivative of rutin Mycobacterium tuberculosis
1.14.19.70 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-phenyl-4H-chromen-4-one
-
 Mycobacterium tuberculosis
1.14.19.70 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-6-phenyl-4H-chromen-4-one best inhibitor Mycobacterium tuberculosis
1.14.19.70 3,5,7-trihydroxy-6-phenyl-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
-
 Mycobacterium tuberculosis
1.14.19.70 5'methylpeltaoside
-
 Mycobacterium tuberculosis
1.14.19.70 caffeic acid
-
 Mycobacterium tuberculosis
1.14.19.70 chlorogenic acid
-
 Mycobacterium tuberculosis
1.14.19.70 epigallocatechin
-
 Mycobacterium tuberculosis
1.14.19.70 kaempferol best inhibitor Mycobacterium tuberculosis
1.14.19.70 myricetin
-
 Mycobacterium tuberculosis
1.14.19.70 peltatoside
-
 Mycobacterium tuberculosis
1.14.19.70 quercetin
-
 Mycobacterium tuberculosis
1.14.19.70 rutin
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 Mycobacterium tuberculosis
-
 mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
-
 ?
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 Mycobacterium tuberculosis H37Rv
-
 mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.70 Mycobacterium tuberculosis P9WPP7
-
-
1.14.19.70 Mycobacterium tuberculosis H37Rv P9WPP7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
-
 Mycobacterium tuberculosis mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
-
 ?
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
-
 Mycobacterium tuberculosis H37Rv mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.70 CYP121
-
 Mycobacterium tuberculosis