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Literature summary extracted from

  • Kugler, P.; Froehlich, D.; Wendisch, V.F.
    Development of a biosensor for crotonobetaine-CoA ligase screening based on the elucidation of Escherichia coli carnitine metabolism (2020), ACS Synth. Biol., 9, 2460-2471.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.48 the biosensing Escherichia coli BW25113 DELTAcai-f ix (Sensor1) strains are assayed by transformation with a vector expressing homologous CaiC variants Citrobacter freundii
6.2.1.48 the biosensing Escherichia coli BW25113 DELTAcai-f ix (Sensor1) strains are assayed by transformation with a vector expressing homologous CaiC variants Malaciobacter marinus
6.2.1.48 the biosensing Escherichia coli BW25113 DELTAcai-f ix (Sensor1) strains are assayed by transformation with a vector expressing homologous CaiC variants Proteus mirabilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.48 ATP + crotonobetaine + CoA Citrobacter freundii
-
 AMP + diphosphate + crotonobetainyl-CoA
-
 ?
6.2.1.48 ATP + crotonobetaine + CoA Proteus mirabilis
-
 AMP + diphosphate + crotonobetainyl-CoA
-
 ?
6.2.1.48 ATP + crotonobetaine + CoA Malaciobacter marinus
-
 AMP + diphosphate + crotonobetainyl-CoA
-
 ?
6.2.1.48 ATP + gamma-butyrobetaine + CoA Citrobacter freundii
-
 AMP + diphosphate + gamma-butyrobetainyl-CoA
-
 ?
6.2.1.48 ATP + gamma-butyrobetaine + CoA Proteus mirabilis
-
 AMP + diphosphate + gamma-butyrobetainyl-CoA
-
 ?
6.2.1.48 ATP + gamma-butyrobetaine + CoA Malaciobacter marinus
-
 AMP + diphosphate + gamma-butyrobetainyl-CoA
-
 ?
6.2.1.48 ATP + L-carnitine + CoA Citrobacter freundii
-
 AMP + diphosphate + L-carnitinyl-CoA
-
 ?
6.2.1.48 ATP + L-carnitine + CoA Proteus mirabilis
-
 AMP + diphosphate + L-carnitinyl-CoA
-
 ?
6.2.1.48 ATP + L-carnitine + CoA Malaciobacter marinus
-
 AMP + diphosphate + L-carnitinyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.48 Citrobacter freundii
-
-
-
6.2.1.48 Malaciobacter marinus
-
-
-
6.2.1.48 Proteus mirabilis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.48 ATP + crotonobetaine + CoA
-
 Citrobacter freundii AMP + diphosphate + crotonobetainyl-CoA
-
 ?
6.2.1.48 ATP + crotonobetaine + CoA
-
 Proteus mirabilis AMP + diphosphate + crotonobetainyl-CoA
-
 ?
6.2.1.48 ATP + crotonobetaine + CoA
-
 Malaciobacter marinus AMP + diphosphate + crotonobetainyl-CoA
-
 ?
6.2.1.48 ATP + gamma-butyrobetaine + CoA
-
 Citrobacter freundii AMP + diphosphate + gamma-butyrobetainyl-CoA
-
 ?
6.2.1.48 ATP + gamma-butyrobetaine + CoA
-
 Proteus mirabilis AMP + diphosphate + gamma-butyrobetainyl-CoA
-
 ?
6.2.1.48 ATP + gamma-butyrobetaine + CoA
-
 Malaciobacter marinus AMP + diphosphate + gamma-butyrobetainyl-CoA
-
 ?
6.2.1.48 ATP + L-carnitine + CoA
-
 Citrobacter freundii AMP + diphosphate + L-carnitinyl-CoA
-
 ?
6.2.1.48 ATP + L-carnitine + CoA
-
 Proteus mirabilis AMP + diphosphate + L-carnitinyl-CoA
-
 ?
6.2.1.48 ATP + L-carnitine + CoA
-
 Malaciobacter marinus AMP + diphosphate + L-carnitinyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.48 betaine:CoA ligase
-
 Citrobacter freundii
6.2.1.48 betaine:CoA ligase
-
 Proteus mirabilis
6.2.1.48 betaine:CoA ligase
-
 Malaciobacter marinus
6.2.1.48 caiC
-
 Citrobacter freundii
6.2.1.48 caiC
-
 Proteus mirabilis
6.2.1.48 caiC
-
 Malaciobacter marinus
6.2.1.48 crotonobetaine-CoA ligase
-
 Citrobacter freundii
6.2.1.48 crotonobetaine-CoA ligase
-
 Proteus mirabilis
6.2.1.48 crotonobetaine-CoA ligase
-
 Malaciobacter marinus

General Information

EC Number General Information Comment Organism
6.2.1.48 evolution this enzyme is conserved not only in the order Enterobacterales but also in Epsilonproteobacteria Citrobacter freundii
6.2.1.48 evolution this enzyme is conserved not only in the order Enterobacterales but also in Epsilonproteobacteria Proteus mirabilis
6.2.1.48 evolution this enzyme is conserved not only in the order Enterobacterales but also in Epsilonproteobacteria Malaciobacter marinus
6.2.1.48 metabolism the enzyme is involved in carnitine metabolism Citrobacter freundii
6.2.1.48 metabolism the enzyme is involved in carnitine metabolism Proteus mirabilis
6.2.1.48 metabolism the enzyme is involved in carnitine metabolism Malaciobacter marinus