Literature summary extracted from

Dong, H.; Godlewska, M.; Wade, M.G.
A rapid assay of human thyroid peroxidase activity (2020), Toxicol. In Vitro, 62, 104662 .

Application

EC Number	Application	Comment	Organism
1.11.1.8	analysis	evaluation of a rapid assay for TPO inhibition, using a stable fluorescent product (Amplex UltraRed). The assay consistently identifies the relative potency of strong to moderate inhibitors and chemicals known to be inactive. Results are less consistent for chemicals reported to be weak inhibitors of rodent TPO	Homo sapiens

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.11.1.8	expression in CHO and LentiX-293 cell	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.11.1.8	2,2',4,4'-tetrahydroxybenzophenone	-	Homo sapiens
1.11.1.8	2-mercaptobenzothiazole	-	Homo sapiens
1.11.1.8	6-Propyl-2-thiouracil	-	Homo sapiens
1.11.1.8	amino-1,2,4-triazole	-	Homo sapiens
1.11.1.8	genistein	-	Homo sapiens
1.11.1.8	Methimazole	-	Homo sapiens
1.11.1.8	resorcinol	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.11.1.8	Homo sapiens	P07202	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)