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Literature summary extracted from

  • Zhang, X.; Xin, Y.; Chen, Z.; Xia, Y.; Xun, L.; Liu, H.
    Sulfide-quinone oxidoreductase is required for cysteine synthesis and indispensable to mitochondrial health (2021), Redox Biol., 47, 102169.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.5.4 gene ht2, quantitative RT-PCR enzyme expression analysis Schizosaccharomyces pombe

Protein Variants

EC Number Protein Variants Comment Organism
1.8.5.4 additional information construction and analysis of an enzyme knockout strain DELTAsqr, phenotypes, overview Schizosaccharomyces pombe

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.5.4 mitochondrion
-
 Schizosaccharomyces pombe 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.5.4 n H2S + n quinone Schizosaccharomyces pombe
-
 polysulfide + n quinol
-
 ?
1.8.5.4 n H2S + n quinone Schizosaccharomyces pombe 972
-
 polysulfide + n quinol
-
 ?
1.8.5.4 n H2S + n quinone Schizosaccharomyces pombe ATCC 24843
-
 polysulfide + n quinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.5.4 Schizosaccharomyces pombe O94284
-
-
1.8.5.4 Schizosaccharomyces pombe 972 O94284
-
-
1.8.5.4 Schizosaccharomyces pombe ATCC 24843 O94284
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.5.4 n H2S + n quinone
-
 Schizosaccharomyces pombe polysulfide + n quinol
-
 ?
1.8.5.4 n H2S + n quinone
-
 Schizosaccharomyces pombe 972 polysulfide + n quinol
-
 ?
1.8.5.4 n H2S + n quinone
-
 Schizosaccharomyces pombe ATCC 24843 polysulfide + n quinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.5.4 HMT2
-
 Schizosaccharomyces pombe
1.8.5.4 SQR
-
 Schizosaccharomyces pombe
1.8.5.4 sulfide-quinone oxidoreductase
-
 Schizosaccharomyces pombe

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.8.5.4 30
-
 assay at Schizosaccharomyces pombe

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.5.4 7.4
-
 assay at Schizosaccharomyces pombe

General Information

EC Number General Information Comment Organism
1.8.5.4 malfunction enzyme Sqr knockout leads to morphological changes and functional deficiencies of mitochondria and apoptosis in Schizosaccharomyces pombe. The Sqr knockout strain displays the same phenotypes as the cysteine-synthesis-deficient strain. Cysteine addition complements the effects caused by Sqr knockout. Sqr knockout also results in physiological changes. The DELTAsqr strain shows reduced cell viability compared to the wild-type strain when cultivated in YES medium. There are more cells of early apoptosis in DELTAsqr culture than that in wild-type culture. Sqr knockout impaires mitochondrial health. Phenotypes and transcription and metabolism changes caused by sqr knockout, overview Schizosaccharomyces pombe
1.8.5.4 metabolism in Schizosaccharomyces pombe, Sqr is the main reactive sulfur species (RSS) producer in mitochondria, and RSS instead of H2S is used by cysteine synthase to synthesize cysteine. In terms of RSS metabolism, Schizosaccharomyces pombe does not contain genes encoding cystathionine beta-synthase (Cbs), cystathionine gamma-lyase (Cse), cysteinyl-tRNA synthetase 2 (Crs2), or persulfide dioxygenase (Pdo) Schizosaccharomyces pombe
1.8.5.4 additional information reactive sulfur species (RSS) include inorganic polysulfide (HSnH, n>2), organic polysulfide (RSnH, n>2), and polysulfane (RSnR, n>2) Schizosaccharomyces pombe
1.8.5.4 physiological function sulfide:quinone oxidoreductase (Sqr), which oxidizes hydrogen sulfide to reactive sulfur species (RSS), is indispensable to mitochondria health in the eukaryotic model microorganism Schizosaccharomyces pombe. RSS play critical functions in the cell, such as signaling, redox homeostasis maintenance, and metabolic regulation Schizosaccharomyces pombe