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Literature summary extracted from

  • Jakubek, M.; Masarik, M.; Briza, T.; Kaplanek, R.; Vesela, K.; Abramenko, N.; Martasek, P.
    PPO-inhibiting herbicides and structurally relevant Schiff bases Evaluation of inhibitory activities against human protoporphyrinogen oxidase (2021), Processes, 9, 1-16 .
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.3.4 expressed in Escherichia coli JM109 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.3.4 acifluorfen
-
 Homo sapiens
1.3.3.4 Atrazine
-
 Homo sapiens
1.3.3.4 butafenacil
-
 Homo sapiens
1.3.3.4 chlornitrofen
-
 Homo sapiens
1.3.3.4 chlortoluron
-
 Homo sapiens
1.3.3.4 ethyl (2,4-dichloro-5-[(E)-[(2-hydroxynaphthalen-1-yl)methylidene]amino]phenoxy)acetate
-
 Homo sapiens
1.3.3.4 ethyl (2,4-dichloro-5-[[(Z)-[4-oxo-2-[(propan-2-yl)oxy]-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]phenoxy)acetate
-
 Homo sapiens
1.3.3.4 ethyl (2,4-dichloro-5-[[(Z)-[6-fluoro-4-oxo-2-[(propan-2-yl)oxy]-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]phenoxy)acetate
-
 Homo sapiens
1.3.3.4 ethyl (2,4-dichloro-5-[[(Z)-[6-nitro-4-oxo-2-[(propan-2-yl)oxy]-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]phenoxy)acetate
-
 Homo sapiens
1.3.3.4 ethyl [2,4-dichloro-5-[(E)-(2,5-dihydroxybenzylidene)amino]phenoxy]acetate
-
 Homo sapiens
1.3.3.4 ethyl [2,4-dichloro-5-[(E)-(2-hydroxy-3-methoxybenzylidene)amino]phenoxy]acetate
-
 Homo sapiens
1.3.3.4 ethyl [2,4-dichloro-5-[(E)-(2-hydroxy-4-methylbenzylidene)amino]phenoxy]acetate
-
 Homo sapiens
1.3.3.4 ethyl [2,4-dichloro-5-[(E)-(5-chloro-2-hydroxybenzylidene)amino]phenoxy]acetate
-
 Homo sapiens
1.3.3.4 formesafen
-
 Homo sapiens
1.3.3.4 lactofen
-
 Homo sapiens
1.3.3.4 methyl 3-[2-chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanylidene-1,3,5-triazinan-1-yl)-4-fluorophenyl]-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxylate i.e. BaR-2 Homo sapiens
1.3.3.4 oxadiargyl
-
 Homo sapiens
1.3.3.4 oxadiazon
-
 Homo sapiens
1.3.3.4 oxyfluorfen
-
 Homo sapiens
1.3.3.4 saflufenacil
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.4 protoporphyrinogen IX + 3 O2 Homo sapiens
-
 protoporphyrin IX + 3 H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.3.4 Ni-NTA column chromatography and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.4 protoporphyrinogen IX + 3 O2
-
 Homo sapiens protoporphyrin IX + 3 H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.3.4 protoporphyrinogen oxidase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.3.4 0.00011
-
 at pH 7.2 and 37°C Homo sapiens formesafen
1.3.3.4 0.00013
-
 at pH 7.2 and 37°C Homo sapiens oxyfluorfen
1.3.3.4 0.00015
-
 at pH 7.2 and 37°C Homo sapiens butafenacil
1.3.3.4 0.00025
-
 at pH 7.2 and 37°C Homo sapiens saflufenacil
1.3.3.4 0.00033
-
 at pH 7.2 and 37°C Homo sapiens lactofen
1.3.3.4 0.00042
-
 at pH 7.2 and 37°C Homo sapiens chlornitrofen
1.3.3.4 0.00085
-
 at pH 7.2 and 37°C Homo sapiens oxadiargyl
1.3.3.4 0.00112
-
 at pH 7.2 and 37°C Homo sapiens acifluorfen
1.3.3.4 0.00192
-
 at pH 7.2 and 37°C Homo sapiens oxadiazon
1.3.3.4 0.00386
-
 at pH 7.2 and 37°C Homo sapiens methyl 3-[2-chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanylidene-1,3,5-triazinan-1-yl)-4-fluorophenyl]-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxylate
1.3.3.4 0.1
-
 IC50 above 0.1 mM, at pH 7.2 and 37°C Homo sapiens Atrazine
1.3.3.4 0.1
-
 IC50 above 0.1 mM, at pH 7.2 and 37°C Homo sapiens ethyl (2,4-dichloro-5-[(E)-[(2-hydroxynaphthalen-1-yl)methylidene]amino]phenoxy)acetate
1.3.3.4 0.1
-
 IC50 above 0.1 mM, at pH 7.2 and 37°C Homo sapiens ethyl (2,4-dichloro-5-[[(Z)-[4-oxo-2-[(propan-2-yl)oxy]-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]phenoxy)acetate
1.3.3.4 0.1
-
 IC50 above 0.1 mM, at pH 7.2 and 37°C Homo sapiens ethyl (2,4-dichloro-5-[[(Z)-[6-fluoro-4-oxo-2-[(propan-2-yl)oxy]-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]phenoxy)acetate
1.3.3.4 0.1
-
 IC50 above 0.1 mM, at pH 7.2 and 37°C Homo sapiens ethyl (2,4-dichloro-5-[[(Z)-[6-nitro-4-oxo-2-[(propan-2-yl)oxy]-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]phenoxy)acetate
1.3.3.4 0.1
-
 IC50 above 0.1 mM, at pH 7.2 and 37°C Homo sapiens ethyl [2,4-dichloro-5-[(E)-(2,5-dihydroxybenzylidene)amino]phenoxy]acetate
1.3.3.4 0.1
-
 IC50 above 0.1 mM, at pH 7.2 and 37°C Homo sapiens ethyl [2,4-dichloro-5-[(E)-(2-hydroxy-3-methoxybenzylidene)amino]phenoxy]acetate
1.3.3.4 0.1
-
 IC50 above 0.1 mM, at pH 7.2 and 37°C Homo sapiens ethyl [2,4-dichloro-5-[(E)-(2-hydroxy-4-methylbenzylidene)amino]phenoxy]acetate
1.3.3.4 0.1
-
 IC50 above 0.1 mM, at pH 7.2 and 37°C Homo sapiens ethyl [2,4-dichloro-5-[(E)-(5-chloro-2-hydroxybenzylidene)amino]phenoxy]acetate
1.3.3.4 0.1
-
 IC50 above 0.1 mM, at pH 7.2 and 37°C Homo sapiens chlortoluron