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Literature summary extracted from

  • Guevara-Flores, A.; Martinez-Gonzalez, J.J.; Herrera-Juarez, A.M.; Rendon, J.L.; Gonzalez-Andrade, M.; Torres Duran, P.V.; Enriquez-Habib, R.G.; Del Arenal Mena, I.P.
    Effect of curcuminoids and curcumin derivate products on thioredoxin-glutathione reductase from Taenia crassiceps cysticerci. Evidence suggesting a curcumin oxidation product as a suitable inhibitor (2019), PLoS ONE, 14, e0220098 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.B1 4-vinylguaiacol
-
 Taenia crassiceps
1.8.1.B1 bis-demethoxycurcumin inhibits in the micromolar concentration range Taenia crassiceps
1.8.1.B1 curcumin time-dependent process. An intermediary compound of curcumin oxidation, probably spiroepoxide, is responsible. Preincubation of curcumin in the presence of NADPH results in the loss of its inhibitory ability. Preincubation of curcumin with sulfhydryl compounds fully protected the enzyme from inhibition Taenia crassiceps
1.8.1.B1 demethoxycurcumin inhibits in the micromolar concentration range Taenia crassiceps
1.8.1.B1 ferulic acid
-
 Taenia crassiceps
1.8.1.B1 ferulic aldehyde
-
 Taenia crassiceps
1.8.1.B1 feruloylmethane
-
 Taenia crassiceps
1.8.1.B1 vanillic acid
-
 Taenia crassiceps
1.8.1.B1 Vanillin
-
 Taenia crassiceps

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.B1 Taenia crassiceps
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.B1 cysticercus
-
 Taenia crassiceps
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.B1 glutathione disulfide + NADPH + H+
-
 Taenia crassiceps 2 glutathione + NADP+
-
 ?
1.8.1.B1 thioredoxin disulfide + NADPH + H+
-
 Taenia crassiceps thioredoxin + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.B1 TGR
-
 Taenia crassiceps
1.8.1.B1 thioredoxin glutathione reductase
-
 Taenia crassiceps

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.B1 0.0129
-
 25°C, pH not specified in the publication Taenia crassiceps 4-vinylguaiacol
1.8.1.B1 0.122
-
 25°C, pH not specified in the publication Taenia crassiceps feruloylmethane
1.8.1.B1 0.127
-
 25°C, pH not specified in the publication Taenia crassiceps Vanillin
1.8.1.B1 0.18
-
 25°C, pH not specified in the publication Taenia crassiceps ferulic aldehyde
1.8.1.B1 0.465
-
 25°C, pH not specified in the publication Taenia crassiceps ferulic acid
1.8.1.B1 0.657
-
 25°C, pH not specified in the publication Taenia crassiceps vanillic acid