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Literature summary extracted from

  • Pinzi, L.; Lherbet, C.; Baltas, M.; Pellati, F.; Rastelli, G.
    In silico repositioning of cannabigerol as a novel inhibitor of the enoyl acyl carrier protein (ACP) reductase (InhA) (2019), Molecules, 24, 2567.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 5-pentyl-2-phenoxyphenol
-
 Mycobacterium tuberculosis
1.3.1.9 cannabichromene 31% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 cis-cannabigerol 78% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 triclosan 56% inhibition at 0.0003 mM Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Mycobacterium tuberculosis P9WGR1
-
-
1.3.1.9 Mycobacterium tuberculosis H37Rv P9WGR1
-
-

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 ACP reductase
-
 Mycobacterium tuberculosis
1.3.1.9 enoyl acyl carrier protein reductase
-
 Mycobacterium tuberculosis
1.3.1.9 InhA
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.9 NADH
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.9 0.0052
-
 at pH 6.8 and 25°C Mycobacterium tuberculosis cis-cannabigerol