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Literature summary extracted from

  • Valiauga, B.; Miseviciene, L.; Rich, M.H.; Ackerley, D.F.; Sarlauskas, J.; Cenas, N.
    Mechanism of two-/four-electron reduction of nitroaromatics by oxygen-insensitive nitroreductases the role of a non-enzymatic reduction step (2018), Molecules, 23, 1672 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.7.1.B3 ascorbate
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.7.1.B3 2,4,6-trinitrophenyl N-methylnitramine + 4 NADPH + H+ Escherichia coli
-
 ?
-
 ?
1.7.1.B3 2,4,6-trinitrotoluene + 2 NADPH + H+ Escherichia coli
-
 ?
-
 ?
1.7.1.B3 4-nitroacetophenone + NADPH + H+ Escherichia coli
-
 ?
-
 ?
1.7.1.B3 4-nitrobenzoic acid + NADPH + H+ Escherichia coli
-
 ?
-
 ?
1.7.1.B3 nitrobenzene + NADPH + H+ Escherichia coli
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.7.1.B3 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.7.1.B3 2,4,6-trinitrophenyl N-methylnitramine + 4 NADPH + H+
-
 Escherichia coli ?
-
 ?
1.7.1.B3 2,4,6-trinitrotoluene + 2 NADPH + H+
-
 Escherichia coli ?
-
 ?
1.7.1.B3 4-nitroacetophenone + NADPH + H+
-
 Escherichia coli ?
-
 ?
1.7.1.B3 4-nitrobenzoic acid + NADPH + H+
-
 Escherichia coli ?
-
 ?
1.7.1.B3 nitrobenzene + NADPH + H+
-
 Escherichia coli ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.7.1.B3 NfsA
-
 Escherichia coli
1.7.1.B3 NR-A
-
 Escherichia coli
1.7.1.B3 oxygen-insensitive NAD(P)H:nitroreductases
-
 Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.7.1.B3 14.2
-
 nitrobenzene at pH 7.0 and 25°C Escherichia coli
1.7.1.B3 59.4
-
 4-Nitroacetophenone at pH 7.0 and 25°C Escherichia coli
1.7.1.B3 64.3
-
 4-nitrobenzoic acid at pH 7.0 and 25°C Escherichia coli
1.7.1.B3 110
-
 2,4,6-trinitrophenyl N-methylnitramine at pH 7.0 and 25°C Escherichia coli
1.7.1.B3 135.1
-
 2,4,6-trinitrotoluene at pH 7.0 and 25°C Escherichia coli

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.7.1.B3 1.5
-
 nitrobenzene at pH 7.0 and 25°C Escherichia coli
1.7.1.B3 2.5
-
 4-nitrobenzoic acid at pH 7.0 and 25°C Escherichia coli
1.7.1.B3 150
-
 4-Nitroacetophenone at pH 7.0 and 25°C Escherichia coli
1.7.1.B3 2700
-
 2,4,6-trinitrotoluene at pH 7.0 and 25°C Escherichia coli
1.7.1.B3 7900
-
 2,4,6-trinitrophenyl N-methylnitramine at pH 7.0 and 25°C Escherichia coli