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Literature summary extracted from

  • Parween, S.; DiNardo, G.; Baj, F.; Zhang, C.; Gilardi, G.; Pandey, A.V.
    Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H (2020), J. Steroid Biochem. Mol. Biol., 196, 105507 .
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.14.14 medicine allelic variants of CYP19A1 when present with a variant form of cytochrome P450 oxidoreductase POR may show different activities, and combined effects of natural variations in both the enzymes should be considered when genetic data are available Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.14 R264C with the wild-type cytochrome P450 oxidoreductase POR as a redox partner, polymorphism R264C shows only 15% of wild-type aromatase activity. With variant P284L-POR as a redox partner, R264C loses all activity but retains 6.7% of activity with P284T-POR Homo sapiens
1.14.14.14 R264H with the wild-type cytochrome P450 oxidoreductase POR as a redox partner, polymorphism R264H shows 87% of wild-type aromatase activity but low activities with both the POR-P284L as well as the POR-P284T variants. The R264H variant has more than threefold higher activity compared to wild-type when the POR-Y607C variant is used as the redox partner Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.14 Homo sapiens P11511
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.14 androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins
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Homo sapiens estrone + formate + 4 H2O + 3 oxidized flavoproteins
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Synonyms

EC Number Synonyms Comment Organism
1.14.14.14 CYP19A1
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Homo sapiens