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Literature summary extracted from

  • Guerrero, S.A.; Arias, D.G.; Cabeza, M.S.; Law, M.C.Y.; DAmico, M.; Kumar, A.; Wilkinson, S.R.
    Functional characterisation of the methionine sulfoxide reductase repertoire in Trypanosoma brucei (2017), Free Radic. Biol. Med., 112, 524-533 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.11 expression in Escherichia coli BL21 (DE3) Trypanosoma brucei brucei
1.8.4.12 expression in Escherichia coli BL21 (DE3) Trypanosoma brucei

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.4.12 0.429
-
 N-acetyl-L-methionine-(R)-S-oxide pH 7.5, 30°C Trypanosoma brucei
1.8.4.12 1.8
-
 tryparedoxin pH 7.5, 30°C Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.4.11 cytosol
-
 Trypanosoma brucei brucei 5829
-
1.8.4.12 mitochondrion
-
 Trypanosoma brucei 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.4.11 21000
-
-
 Trypanosoma brucei brucei
1.8.4.12 20000
-
-
 Trypanosoma brucei

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Trypanosoma brucei brucei Q57YH5
-
-
1.8.4.11 Trypanosoma brucei brucei 927/4 GUTat10.1 Q57YH5
-
-
1.8.4.12 Trypanosoma brucei
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.4.11
-
 Trypanosoma brucei brucei
1.8.4.12
-
 Trypanosoma brucei

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.11 trypomastigote
-
 Trypanosoma brucei brucei
-
1.8.4.12 trypomastigote
-
 Trypanosoma brucei
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.12 N-acetyl-L-methionine-(R)-S-oxide + tryparedoxin
-
 Trypanosoma brucei N-acetyl-L-methionine + tryparedoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 TbmsrA
-
 Trypanosoma brucei brucei
1.8.4.12 TbmsrB
-
 Trypanosoma brucei

General Information

EC Number General Information Comment Organism
1.8.4.11 physiological function to combat the deleterious effects that oxidation of the sulfur atom in methionine to sulfoxide may bring, aerobic cells express repair pathways involving methionine sulfoxide reductases (MSRs) to reverse the deleterious reaction Trypanosoma brucei brucei
1.8.4.12 physiological function to combat the deleterious effects that oxidation of the sulfur atom in methionine to sulfoxide may bring, aerobic cells express repair pathways involving methionine sulfoxide reductases (MSRs) to reverse the deleterious reaction Trypanosoma brucei