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Literature summary extracted from

  • Lu, Y.; Shao, M.; Wu, T.
    Kynurenine-3-monooxygenase a new direction for the treatment in different diseases (2020), Food Sci. Nutr., 8, 711-719 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.9 mitochondrial outer membrane
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Homo sapiens 5741
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.9 L-kynurenine + NADPH + H+ + O2 Homo sapiens
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3-hydroxy-L-kynurenine + NADP+ + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.9 Homo sapiens O15229
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.9 kidney
-
Homo sapiens
-
1.14.13.9 liver
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.9 L-kynurenine + NADPH + H+ + O2
-
Homo sapiens 3-hydroxy-L-kynurenine + NADP+ + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.9 KMO
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Homo sapiens
1.14.13.9 kynurenine-3-monooxygenase
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Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.9 FAD
-
Homo sapiens
1.14.13.9 NADPH
-
Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.13.9 malfunction neuroprotection of KMO inhibition through accumulation of kynureninic acid (KYNA) has neuroprotective effects and results in attenuation of NMDA receptor function Homo sapiens
1.14.13.9 metabolism the kynurenine pathway (KP) is the principal pathway for the metabolism of tryptophan (TRY) involving the enzyme, pathway overview Homo sapiens
1.14.13.9 physiological function kynurenine-3-monooxygenase (KMO) is an enzyme that relies on nicotinamide adenine dinucleotide phosphate (NADP), a key site in the kynurenine pathway (KP), which has great effects on neurological diseases, cancer, and peripheral inflammation. Enzyme controlling the chief division of the KP, which directly controls downstream product quinolinic acid (QUIN) and indirectly controls kynurenic acid (KYNA), plays an important role in many diseases, especially neurological diseases. Role of KMO in different neurological diseases, such as Huntington's disease, schizophrenia, ischemic stroke and neuropathic headache, Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis, as well as in non-neurological diseases, such as acute pancreatitis and hepatocellular carcinoma, mechanisms, detailed overview Homo sapiens