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Literature summary extracted from

  • Dogan, S.D.; Guenduez, M.G.; Dogan, H.; Krishna, V.S.; Lherbet, C.; Sriram, D.
    Design and synthesis of thiourea-based derivatives as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors (2020), Eur. J. Med. Chem., 199, 112402 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 1-(2,4-dichlorophenyl)-3-(3-methylpyridin-2-yl)thiourea 47% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(2-bromobenzyl)-3-(4-nitrophenyl)thiourea 78% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(2-bromobenzyl)-3-phenylthiourea 23% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(2-chlorobenzyl)-3-(4-nitrophenyl)thiourea 72% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(2-chlorobenzyl)-3-phenylthiourea 31% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(2-chlorobenzyl)-3-phenylurea 14% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-methylpyridin-2-yl)thiourea 22% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(3-methylpyridin-2-yl)-3-(2-(trifluoromethyl)phenyl)thiourea 32% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(3-methylpyridin-2-yl)-3-(4-tolyl)thiourea 23% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(3-methylpyridin-2-yl)-3-(naphthalen-2-yl)thiourea 38% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(3-methylpyridin-2-yl)-3-phenylthiourea 35% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(4-bromophenyl)-3-(3-methylpyridin-2-yl)thiourea 25% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(4-fluorophenyl)-3-(3-methylpyridin-2-yl)thiourea 17% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(4-iodophenyl)-3-(3-methylpyridin-2-yl)thiourea 8% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 1-(4-methoxyphenyl)-3-(3-methylpyridin-2-yl)thiourea 20% inhibition at 0.05 mM Mycobacterium tuberculosis
1.3.1.9 bedaquiline
-
 Mycobacterium tuberculosis
1.3.1.9 delamanid
-
 Mycobacterium tuberculosis
1.3.1.9 ethambutol
-
 Mycobacterium tuberculosis
1.3.1.9 isoniazid
-
 Mycobacterium tuberculosis
1.3.1.9 noxytiolin
-
 Mycobacterium tuberculosis
1.3.1.9 rifampicin
-
 Mycobacterium tuberculosis
1.3.1.9 thioacetazone
-
 Mycobacterium tuberculosis
1.3.1.9 thiocarlide
-
 Mycobacterium tuberculosis
1.3.1.9 thiopental
-
 Mycobacterium tuberculosis
1.3.1.9 triclosan more than 99% inhibition at 0.05 mM Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Mycobacterium tuberculosis P9WGR1
-
-
1.3.1.9 Mycobacterium tuberculosis H37Rv P9WGR1
-
-

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 enoyl acyl carrier protein reductase
-
 Mycobacterium tuberculosis
1.3.1.9 InhA
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.9 0.0156
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis 1-(2-bromobenzyl)-3-phenylthiourea
1.3.1.9 0.0177
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis 1-(2-chlorobenzyl)-3-(4-nitrophenyl)thiourea